Estrogen formation by the ovary of the rabbit embryo

Leon Milewich, Fredrick W. George, Jean D. Wilson

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The conversion of [1,2,6,7-3H]-testosterone to radioactive estradiol was assessed in tissue slices of 18 different tissues from rabbit embryos that varied in age from 16 to 29 days gestation. Significant rates of estradiol synthesis were demonstrated only in ovaries [4.2 ± 0.7 (mean ± SEM) pmol/h/mg protein], placenta (0.7 ± 0.2 pmol/h/mg protein) and brain (0.3 ±0.1 pmol/h/mg protein). Estradiol formation was undetectable in day 16 gonads of both sexes and in testes at all ages examined, but by day 18 it was demonstrable in ovaries and rose rapidly to reach a level of 6 pmol/h/mg protein by day 19. The time of appearance of the enzymatic capacity to convert testosterone to estradiol in the ovary is similar to the onset of the enzymatic capacity to form testosterone by the fetal testis, suggesting that the acquisition of the enzymatic activities that allow specific endocrine function by these two tissues may be regulated by the same or similar factors during embryonic development.

Original languageEnglish (US)
Pages (from-to)187-196
Number of pages10
Issue number1
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Endocrinology


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