Estrogen receptors in pain modulation: cellular signaling

Qing Chen, Wenxin Zhang, Neeti Sadana, Xinzhong Chen

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Sensory perception and emotional disorders are disproportionally represented in men and women and are thus thought to be modulated by different sex hormones in various conditions. Among the most important hormones perceived to affect sensory processing and transduction is estrogen. Numerous previous researchers have endeavored to demonstrate that estrogen is capable of modulating the activity of sensory neurons in peripheral and central sites in female, male, or castrated animals. However, the underlying mechanisms of its modulation of neuronal activity are somewhat unclear. In the present review, we discuss the possible cellular and molecular mechanisms involved in the modulation of nociception by estrogen.

Original languageEnglish (US)
Article number22
JournalBiology of Sex Differences
Volume12
Issue number1
DOIs
StatePublished - Dec 2021
Externally publishedYes

ASJC Scopus subject areas

  • Gender Studies
  • Endocrinology

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