Eukaryotic Ribosome Assembly and Nuclear Export

Purnima Nerurkar, Martin Altvater, Stefan Gerhardy, Sabina Schütz, Ute Fischer, Christine Weirich, Vikram Govind Panse

Research output: Chapter in Book/Report/Conference proceedingConference contribution

49 Scopus citations

Abstract

Accurate translation of the genetic code into functional polypeptides is key to cellular growth and proliferation. This essential process is carried out by the ribosome, a ribonucleoprotein complex of remarkable size and intricacy. Although the structure of the mature ribosome has provided insight into the mechanism of translation, our knowledge regarding the assembly, quality control, and intracellular targeting of this molecular machine is still emerging. Assembly of the eukaryotic ribosome begins in the nucleolus and requires more than 350 conserved assembly factors, which transiently associate with the preribosome at specific maturation stages. After accomplishing their tasks, early-acting. assembly factors are released, preparing preribosomes for nuclear export. Export competent preribosomal subunits are transported through nuclear pore complexes into the cytoplasm, where they undergo final maturation steps, which are closely connected to quality control, before engaging in translation. In this chapter, we focus on the final events that commit correctly assembled ribosomal subunits for translation.

Original languageEnglish (US)
Title of host publicationInternational Review of Cell and Molecular Biology, 2015
PublisherElsevier Inc.
Pages107-140
Number of pages34
Volume319
ISBN (Print)9780128022788
DOIs
StatePublished - Jan 1 2015

Publication series

NameInternational Review of Cell and Molecular Biology
Volume319
ISSN (Print)1937-6448

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Keywords

  • 40S subunits
  • 60S subunits
  • Biogenesis
  • Eukaryotic cells
  • Nuclear transport
  • Ribosome

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Nerurkar, P., Altvater, M., Gerhardy, S., Schütz, S., Fischer, U., Weirich, C., & Panse, V. G. (2015). Eukaryotic Ribosome Assembly and Nuclear Export. In International Review of Cell and Molecular Biology, 2015 (Vol. 319, pp. 107-140). (International Review of Cell and Molecular Biology; Vol. 319). Elsevier Inc.. https://doi.org/10.1016/bs.ircmb.2015.07.002