Evaluating Glutamatergic Transmission in Schizophrenia

Carol A. Tamminga; Adrienne C. Lahti; Deborah R. Medoff; Xue Min Gao; Henry H. Holcomb

doi:10.1196/annals.1300.062

Evaluating Glutamatergic Transmission in Schizophrenia

Carol A. Tamminga, Adrienne C. Lahti, Deborah R. Medoff, Xue Min Gao, Henry H. Holcomb

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Our findings with schizophrenia and the glutamate system have relied on the characterization of the clinical response of patients to ketamine and their functional brain imaging response (rCBF) to the drug. Prior to the human studies reported here, we had evaluated the region activation characteristics and pharmacology of PCP and its congener MK 801 in animals. What I will report in this paper has been individually reported elsewhere but brought together here in a new synthesis.

Original language	English (US)
Pages (from-to)	113-118
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	1003
DOIs	https://doi.org/10.1196/annals.1300.062
State	Published - Nov 2003

Keywords

Glutamatergic system
Ketamine
MK-801
Molecular targets
PCP
Psychosis
Schizophrenia

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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AU - Holcomb, Henry H.

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Evaluating Glutamatergic Transmission in Schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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