Evaluation and management of neurogenic vesicourethral dysfunction in multiple sclerosis

Sophie G. Fletcher, Gary E. Lemack

Research output: Contribution to journalArticle

Abstract

Multiple sclerosis (MS), a chronic inflammatory disease of the nervous system, is the most common cause of progressive neurologic disability in young adults. In addition to spasticity, tremors, weakness, sensory disturbances, depression, cognitive problems, and sexual dysfunction, neurogenic vesicourethral dysfunction (VUD) is a prevalent and destructive manifestation of the disease that severely affects quality of life. Evaluation of this disorder requires insight into the progressive yet unpredictable neurologic changes caused by MS. Urinary symptoms are poorly specific for the presence of VUD, although duration of disease and disability status do correlate with adverse urodynamic findings. Limited evidence exists regarding exactly when urodynamic evaluation should be initiated upon referral, although an algorithm following urinary retention can serve as a guide. This review aims to detail what is currently known regarding the evaluation and management of VUD in MS such that a flexible, patient-centered approach can be implemented.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalCurrent Bladder Dysfunction Reports
Volume4
Issue number2
DOIs
StatePublished - 2009

Fingerprint

Nervous System
Multiple Sclerosis
Urodynamics
Urinary Retention
Neurology
Tremor
Young Adult
Chronic Disease
Referral and Consultation
Quality of Life

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Evaluation and management of neurogenic vesicourethral dysfunction in multiple sclerosis. / Fletcher, Sophie G.; Lemack, Gary E.

In: Current Bladder Dysfunction Reports, Vol. 4, No. 2, 2009, p. 71-78.

Research output: Contribution to journalArticle

@article{d5c07008ec4b484ea6933c38f73d9d43,
title = "Evaluation and management of neurogenic vesicourethral dysfunction in multiple sclerosis",
abstract = "Multiple sclerosis (MS), a chronic inflammatory disease of the nervous system, is the most common cause of progressive neurologic disability in young adults. In addition to spasticity, tremors, weakness, sensory disturbances, depression, cognitive problems, and sexual dysfunction, neurogenic vesicourethral dysfunction (VUD) is a prevalent and destructive manifestation of the disease that severely affects quality of life. Evaluation of this disorder requires insight into the progressive yet unpredictable neurologic changes caused by MS. Urinary symptoms are poorly specific for the presence of VUD, although duration of disease and disability status do correlate with adverse urodynamic findings. Limited evidence exists regarding exactly when urodynamic evaluation should be initiated upon referral, although an algorithm following urinary retention can serve as a guide. This review aims to detail what is currently known regarding the evaluation and management of VUD in MS such that a flexible, patient-centered approach can be implemented.",
author = "Fletcher, {Sophie G.} and Lemack, {Gary E.}",
year = "2009",
doi = "10.1007/s11884-009-0011-5",
language = "English (US)",
volume = "4",
pages = "71--78",
journal = "Current Bladder Dysfunction Reports",
issn = "1931-7212",
publisher = "Current Medicine Group",
number = "2",

}

TY - JOUR

T1 - Evaluation and management of neurogenic vesicourethral dysfunction in multiple sclerosis

AU - Fletcher, Sophie G.

AU - Lemack, Gary E.

PY - 2009

Y1 - 2009

N2 - Multiple sclerosis (MS), a chronic inflammatory disease of the nervous system, is the most common cause of progressive neurologic disability in young adults. In addition to spasticity, tremors, weakness, sensory disturbances, depression, cognitive problems, and sexual dysfunction, neurogenic vesicourethral dysfunction (VUD) is a prevalent and destructive manifestation of the disease that severely affects quality of life. Evaluation of this disorder requires insight into the progressive yet unpredictable neurologic changes caused by MS. Urinary symptoms are poorly specific for the presence of VUD, although duration of disease and disability status do correlate with adverse urodynamic findings. Limited evidence exists regarding exactly when urodynamic evaluation should be initiated upon referral, although an algorithm following urinary retention can serve as a guide. This review aims to detail what is currently known regarding the evaluation and management of VUD in MS such that a flexible, patient-centered approach can be implemented.

AB - Multiple sclerosis (MS), a chronic inflammatory disease of the nervous system, is the most common cause of progressive neurologic disability in young adults. In addition to spasticity, tremors, weakness, sensory disturbances, depression, cognitive problems, and sexual dysfunction, neurogenic vesicourethral dysfunction (VUD) is a prevalent and destructive manifestation of the disease that severely affects quality of life. Evaluation of this disorder requires insight into the progressive yet unpredictable neurologic changes caused by MS. Urinary symptoms are poorly specific for the presence of VUD, although duration of disease and disability status do correlate with adverse urodynamic findings. Limited evidence exists regarding exactly when urodynamic evaluation should be initiated upon referral, although an algorithm following urinary retention can serve as a guide. This review aims to detail what is currently known regarding the evaluation and management of VUD in MS such that a flexible, patient-centered approach can be implemented.

UR - http://www.scopus.com/inward/record.url?scp=84873320715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873320715&partnerID=8YFLogxK

U2 - 10.1007/s11884-009-0011-5

DO - 10.1007/s11884-009-0011-5

M3 - Article

AN - SCOPUS:84873320715

VL - 4

SP - 71

EP - 78

JO - Current Bladder Dysfunction Reports

JF - Current Bladder Dysfunction Reports

SN - 1931-7212

IS - 2

ER -