Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy

Jianwei Cao, Bilal Khan, Nathan Hervey, Fenghua Tian, Mauricio R. Delgado, Nancy J. Clegg, Linsley Smith, Heather Roberts, Kirsten Tulchin-Francis, Angela Shierk, Laura Shagman, Duncan Macfarlane, Hanli Liu, George Alexandrakis

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Sensorimotor cortex plasticity induced by constraint-induced movement therapy (CIMT) in six children (10.2 ± 2.1 years old) with hemiplegic cerebral palsy was assessed by functional near-infrared spectroscopy (fNIRS). The activation laterality index and time-to-peak/duration during a finger-tapping task and the resting- state functional connectivity were quantified before, immediately after, and 6 months after CIMT. These fNIRS-based metrics were used to help explain changes in clinical scores of manual performance obtained concurrently with imaging time points. Five age-matched healthy children (9.8 ± 1.3 years old) were also imaged to provide comparative activation metrics for normal controls. Interestingly, the activation time-to-peak/duration for all sensorimotor centers displayed significant normalization immediately after CIMT that persisted 6 months later. In contrast to this improved localized activation response, the laterality index and resting-state connectivity metrics that depended on communication between sensorimotor centers improved immediately after CIMT, but relapsed 6 months later. In addition, for the subjects measured in this work, there was either a trade-off between improving unimanual versus bimanual performance when sensorimotor activation patterns normalized after CIMT, or an improvement occurred in both unimanual and bimanual performance but at the cost of very abnormal plastic changes in sensorimotor activity.

Original languageEnglish (US)
Article number046009
JournalJournal of Biomedical Optics
Volume20
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • cerebral palsy
  • constraint-induced movement therapy
  • functional near-infrared spectroscopy
  • resting-state functional connectivity
  • sensorimotor cortex

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy'. Together they form a unique fingerprint.

  • Cite this

    Cao, J., Khan, B., Hervey, N., Tian, F., Delgado, M. R., Clegg, N. J., Smith, L., Roberts, H., Tulchin-Francis, K., Shierk, A., Shagman, L., Macfarlane, D., Liu, H., & Alexandrakis, G. (2015). Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy. Journal of Biomedical Optics, 20(4), [046009]. https://doi.org/10.1117/1.JBO.20.4.046009