Evaluation of major parotid glycoproteins in patients with burning mouth syndrome

F. T. Lundy, I. Al-Hashimi, T. D. Rees, P. J. Lamey

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Objective. This study was to investigate the potential role of salivary glycoproteins in burning mouth syndrome. Study design. This study compared major parotid glycoproteins in a group of patients with burning mouth syndrome and age-, sex-, race-matched healthy controls. Results. By use of a glycoprotein detection kit, saliva from both patients and controls exhibited three major parotid glycoprotein banding patterns consisting of either one or two bands, molecular weights 58 kDa and 77 kDa. The strong lectin reactivity of major parotid glycoproteins with Ricinus communis agglutinin suggests that galactose is the most prevalent terminal sugar. In addition, major parotid glycoproteins were shown to express blood group antigen H. On the basis of metachromatic characteristics and immunologic reactivity, major parotid glycoproteins appear to be members of the proline rich protein multigene family, proline rich glycoprotein, genetic polymorphism G1. No qualitative difference was observed in major parotid glycoprotein banding patterns between patients and controls. Conclusion. These findings do not support a role for major parotid glycoproteins in burning mouth syndrome.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume83
Issue number2
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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