TY - JOUR
T1 - Evaluation of major parotid glycoproteins in patients with burning mouth syndrome
AU - Lundy, F. T.
AU - Al-Hashimi, I.
AU - Rees, T. D.
AU - Lamey, P. J.
N1 - Funding Information:
This work was supported by travel awards from The Wellcome Trust and The Oral and Dental Research Trust and in part by UPHS Grant DE10658. aResearch Fellow, School of Clinical Dentistry, The Queen's University of Belfast. bDirector, Salivary Dysfunction Clinic, Department of Periodontics, Baylor College of Dentistry. Cprofessor, Department of Periodontics, Baylor College of Den-fistry. dProfessor, School of Clinical Dentistry, The Queen's University of Belfast. Received for publication June 6, 1996; returned for revision July 19, 1996; accepted for publication Aug. 27, 1996. Copyright © 1997 by Mosby-Year Book, Inc. 1079-2104/97/$5.00 + 0 7/13/77718
PY - 1997
Y1 - 1997
N2 - Objective. This study was to investigate the potential role of salivary glycoproteins in burning mouth syndrome. Study design. This study compared major parotid glycoproteins in a group of patients with burning mouth syndrome and age-, sex-, race-matched healthy controls. Results. By use of a glycoprotein detection kit, saliva from both patients and controls exhibited three major parotid glycoprotein banding patterns consisting of either one or two bands, molecular weights 58 kDa and 77 kDa. The strong lectin reactivity of major parotid glycoproteins with Ricinus communis agglutinin suggests that galactose is the most prevalent terminal sugar. In addition, major parotid glycoproteins were shown to express blood group antigen H. On the basis of metachromatic characteristics and immunologic reactivity, major parotid glycoproteins appear to be members of the proline rich protein multigene family, proline rich glycoprotein, genetic polymorphism G1. No qualitative difference was observed in major parotid glycoprotein banding patterns between patients and controls. Conclusion. These findings do not support a role for major parotid glycoproteins in burning mouth syndrome.
AB - Objective. This study was to investigate the potential role of salivary glycoproteins in burning mouth syndrome. Study design. This study compared major parotid glycoproteins in a group of patients with burning mouth syndrome and age-, sex-, race-matched healthy controls. Results. By use of a glycoprotein detection kit, saliva from both patients and controls exhibited three major parotid glycoprotein banding patterns consisting of either one or two bands, molecular weights 58 kDa and 77 kDa. The strong lectin reactivity of major parotid glycoproteins with Ricinus communis agglutinin suggests that galactose is the most prevalent terminal sugar. In addition, major parotid glycoproteins were shown to express blood group antigen H. On the basis of metachromatic characteristics and immunologic reactivity, major parotid glycoproteins appear to be members of the proline rich protein multigene family, proline rich glycoprotein, genetic polymorphism G1. No qualitative difference was observed in major parotid glycoprotein banding patterns between patients and controls. Conclusion. These findings do not support a role for major parotid glycoproteins in burning mouth syndrome.
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U2 - 10.1016/S1079-2104(97)90013-5
DO - 10.1016/S1079-2104(97)90013-5
M3 - Article
C2 - 9117758
AN - SCOPUS:0031065215
SN - 1079-2104
VL - 83
SP - 252
EP - 258
JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
IS - 2
ER -