Evaluation of new anti-infective drugs for the treatment of osteomyelitis in adults

J. T. Mader, C. Norden, J. D. Nelson, G. B. Calandra

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44 Scopus citations


Cases of osteomyelitis can be divided into four categories: acute hematogenous, vertebral, secondary to a contiguous focus of infection without vascular disease, and secondary to a contiguous focus of infection with vascular disease. Each category may be further divided into acute and chronic forms. Clinical symptoms persisting for >10 days correlate roughly with the development of necrotic bone and chronic osteomyelitis. Patients enrolled in clinical trials should generally be >12 years of age. Prior antimicrobial treatment does not exclude patients if the culture of a bone sample obtained at the time of enrollment yields pathogenic bacteria. Randomized, double-blind, active-control comparative studies are encouraged. Clinical outcome should be assessed during therapy and within 5-9 days, 4-6 weeks, and 11-13 months after completion of therapy. In the final assessment, clinical appraisal is paramount.

Original languageEnglish (US)
Pages (from-to)S155-S161
JournalClinical Infectious Diseases
StatePublished - Nov 1992


ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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