Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

Kentaro Hirose, Alexander Y. Payumo, Stephen Cutie, Alison Hoang, Hao Zhang, Romain Guyot, Dominic Lunn, Rachel B. Bigley, Hongyao Yu, Jiajia Wang, Megan Smith, Ellen Gillett, Sandra E. Muroy, Tobias Schmid, Emily Wilson, Kenneth A. Field, Dee Ann M. Reeder, Malcom Maden, Michael M. Yartsev, Michael J. Wolfgang & 8 others Frank Grützner, Thomas S. Scanlan, Luke Ignatius Szweda, Rochelle Buffenstein, Guang Hu, Frederic Flamant, Jeffrey E. Olgin, Guo N. Huang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber's law-the 3/4-power law scaling of metabolism with bodyweight-and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy.

Original languageEnglish (US)
Pages (from-to)184-188
Number of pages5
JournalScience
Volume364
Issue number6436
DOIs
StatePublished - Jan 1 2019

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Thyroid Hormones
Cardiac Myocytes
Zebrafish
Phylogeny
Cell Cycle Checkpoints
Body Temperature
Diploidy
Thyroxine
Regeneration
Mammals
Cell Cycle
Serum

ASJC Scopus subject areas

  • General

Cite this

Hirose, K., Payumo, A. Y., Cutie, S., Hoang, A., Zhang, H., Guyot, R., ... Huang, G. N. (2019). Evidence for hormonal control of heart regenerative capacity during endothermy acquisition. Science, 364(6436), 184-188. https://doi.org/10.1126/science.aar2038

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition. / Hirose, Kentaro; Payumo, Alexander Y.; Cutie, Stephen; Hoang, Alison; Zhang, Hao; Guyot, Romain; Lunn, Dominic; Bigley, Rachel B.; Yu, Hongyao; Wang, Jiajia; Smith, Megan; Gillett, Ellen; Muroy, Sandra E.; Schmid, Tobias; Wilson, Emily; Field, Kenneth A.; Reeder, Dee Ann M.; Maden, Malcom; Yartsev, Michael M.; Wolfgang, Michael J.; Grützner, Frank; Scanlan, Thomas S.; Szweda, Luke Ignatius; Buffenstein, Rochelle; Hu, Guang; Flamant, Frederic; Olgin, Jeffrey E.; Huang, Guo N.

In: Science, Vol. 364, No. 6436, 01.01.2019, p. 184-188.

Research output: Contribution to journalArticle

Hirose, K, Payumo, AY, Cutie, S, Hoang, A, Zhang, H, Guyot, R, Lunn, D, Bigley, RB, Yu, H, Wang, J, Smith, M, Gillett, E, Muroy, SE, Schmid, T, Wilson, E, Field, KA, Reeder, DAM, Maden, M, Yartsev, MM, Wolfgang, MJ, Grützner, F, Scanlan, TS, Szweda, LI, Buffenstein, R, Hu, G, Flamant, F, Olgin, JE & Huang, GN 2019, 'Evidence for hormonal control of heart regenerative capacity during endothermy acquisition', Science, vol. 364, no. 6436, pp. 184-188. https://doi.org/10.1126/science.aar2038
Hirose K, Payumo AY, Cutie S, Hoang A, Zhang H, Guyot R et al. Evidence for hormonal control of heart regenerative capacity during endothermy acquisition. Science. 2019 Jan 1;364(6436):184-188. https://doi.org/10.1126/science.aar2038
Hirose, Kentaro ; Payumo, Alexander Y. ; Cutie, Stephen ; Hoang, Alison ; Zhang, Hao ; Guyot, Romain ; Lunn, Dominic ; Bigley, Rachel B. ; Yu, Hongyao ; Wang, Jiajia ; Smith, Megan ; Gillett, Ellen ; Muroy, Sandra E. ; Schmid, Tobias ; Wilson, Emily ; Field, Kenneth A. ; Reeder, Dee Ann M. ; Maden, Malcom ; Yartsev, Michael M. ; Wolfgang, Michael J. ; Grützner, Frank ; Scanlan, Thomas S. ; Szweda, Luke Ignatius ; Buffenstein, Rochelle ; Hu, Guang ; Flamant, Frederic ; Olgin, Jeffrey E. ; Huang, Guo N. / Evidence for hormonal control of heart regenerative capacity during endothermy acquisition. In: Science. 2019 ; Vol. 364, No. 6436. pp. 184-188.
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AU - Grützner, Frank

AU - Scanlan, Thomas S.

AU - Szweda, Luke Ignatius

AU - Buffenstein, Rochelle

AU - Hu, Guang

AU - Flamant, Frederic

AU - Olgin, Jeffrey E.

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