Evolution of a signalling system that incorporates both redundancy and diversity: Arabidopsis SUMOylation

Renee Chosed, Sohini Mukherjee, Luisa Maria Lois, Kim Orth

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The reversible post-translational modifier, SUMO (small ubiquitin-related modifier), modulates the activity of a diverse set of target proteins, resulting in important consequences to the cellular machinery. Conjugation machinery charges the processed SUMO so that it can be linked via an isopeptide bond to a target protein. The removal of SUMO moieties from conjugated proteins by isopeptidases regenerates pools of processed SUMOs and unmodified target proteins. The evolutionarily conserved SUMO-conjugating proteins, E1 and E2, recognize a diverse set of Arabidopsis SUMO proteins using them to modify protein substrates. In contrast, the deSUMOylating enzymes differentially recognize the Arabidopsis SUMO proteins, resulting in specificity of the deconjugating machinery. The specificity of the Arabidopsis deSUMOylating enzymes is further diversified by the addition of regulatory domains. Therefore the SUMO proteins, in this signalling system, have evolved to contain information that allows not only redundancy with the conjugation system but also diversity with the deconjugating enzymes.

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalBiochemical Journal
Volume398
Issue number3
DOIs
StatePublished - Sep 15 2006

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Keywords

  • Arabidopsis thaliana
  • Reversible post-translational modification
  • SUMOylation
  • Signalling system
  • Small ubiquitin-related modifier (SUMO)
  • Ubiquitin-like protein protease-1 (ULP1)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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