Evolving evidence in adult idiopathic intracranial hypertension: Pathophysiology and management

Susan P. Mollan, Fizzah Ali, Ghaniah Hassan-Smith, Hannah Botfield, Deborah I Friedman, Alexandra J. Sinclair

Research output: Contribution to journalReview article

65 Scopus citations

Abstract

Idiopathic intracranial hypertension (IIH) is a rare but important disease associated with significant morbidity. There is an expected rise in prevalence in line with the escalating global burden of obesity. Modern revisions in the terminology and diagnostic criteria for IIH help guide clinicians in investigations and researchers in standardising recruitment criteria for clinical trials. The pathophysiology of IIH is incompletely characterised; suggested underpinning mechanisms include the role of cerebrospinal fluid regulation as well as metabolic and endocrinological perspectives. Recent treatment trials are providing insights into the management but debate still surrounds key areas in treatment. This review will provide an up-to-date discussion on the potential pathogenic mechanisms and management of IIH.

Original languageEnglish (US)
Pages (from-to)982-992
Number of pages11
JournalJournal of Neurology, Neurosurgery and psychiatry
Volume87
Issue number9
DOIs
StatePublished - Sep 1 2016

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Keywords

  • BENIGN INTRACRAN HYP
  • CSF DYNAMICS
  • HEADACHE
  • NEUROOPHTHALMOLOGY

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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