Evolving evidence in adult idiopathic intracranial hypertension

Pathophysiology and management

Susan P. Mollan, Fizzah Ali, Ghaniah Hassan-Smith, Hannah Botfield, Deborah I Friedman, Alexandra J. Sinclair

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Idiopathic intracranial hypertension (IIH) is a rare but important disease associated with significant morbidity. There is an expected rise in prevalence in line with the escalating global burden of obesity. Modern revisions in the terminology and diagnostic criteria for IIH help guide clinicians in investigations and researchers in standardising recruitment criteria for clinical trials. The pathophysiology of IIH is incompletely characterised; suggested underpinning mechanisms include the role of cerebrospinal fluid regulation as well as metabolic and endocrinological perspectives. Recent treatment trials are providing insights into the management but debate still surrounds key areas in treatment. This review will provide an up-to-date discussion on the potential pathogenic mechanisms and management of IIH.

Original languageEnglish (US)
JournalJournal of Neurology, Neurosurgery and Psychiatry
DOIs
StateAccepted/In press - Feb 17 2016

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Pseudotumor Cerebri
Rare Diseases
Terminology
Cerebrospinal Fluid
Obesity
Research Personnel
Clinical Trials
Morbidity
Hypertension

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

Cite this

Evolving evidence in adult idiopathic intracranial hypertension : Pathophysiology and management. / Mollan, Susan P.; Ali, Fizzah; Hassan-Smith, Ghaniah; Botfield, Hannah; Friedman, Deborah I; Sinclair, Alexandra J.

In: Journal of Neurology, Neurosurgery and Psychiatry, 17.02.2016.

Research output: Contribution to journalArticle

Mollan, Susan P. ; Ali, Fizzah ; Hassan-Smith, Ghaniah ; Botfield, Hannah ; Friedman, Deborah I ; Sinclair, Alexandra J. / Evolving evidence in adult idiopathic intracranial hypertension : Pathophysiology and management. In: Journal of Neurology, Neurosurgery and Psychiatry. 2016.
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