Evolving perspectives on the etiology and pathogenesis of acne vulgaris

Lawrence F. Eichenfield, James Q. Del Rosso, Anthony J. Mancini, Fran Cook-Bolden, Linda Stein Gold, Seemal Desai, Jonathan Weiss, David Pariser, Joshua Zeichner, Neal Bhatia, Leon Kircik

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

As the pathophysiology of acne is complex and multifactorial, the continued influx of new basic science and clinical information requires careful analysis before drawing conclusions about what truly contributes to the development and progression of this chronic disease. Our objective is to review the latest evidence and highlight a number of important perspectives on the pathophysiology of acne. An improved understanding of acne pathogenesis should lead to more rational therapy and a better understanding of the role of P acnes opens new perspectives for the development of new treatments and management. Further research may be directed at targeting receptors, adhesion molecules, cytokines, chemokines or other pro-inflammatory targets implicated in the activation of immune detection and response (i.e., toll-like receptors [TLRs], protease-activated receptors [PARs]) that appear to contribute to the pathophysiology of acne. Therapeutic options that reduce the need for topical and/or oral antibiotic therapy for acne are welcome as bacterial resistance to antibiotics is a clinically relevant concern both in the United States and globally.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalJournal of Drugs in Dermatology
Volume14
Issue number3
StatePublished - Mar 1 2015

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Acne Vulgaris
Information Science
Proteinase-Activated Receptors
Bacterial Drug Resistance
Toll-Like Receptors
Chemokines
Chronic Disease
Therapeutics
Cytokines
Anti-Bacterial Agents
Research

ASJC Scopus subject areas

  • Dermatology

Cite this

Eichenfield, L. F., Del Rosso, J. Q., Mancini, A. J., Cook-Bolden, F., Gold, L. S., Desai, S., ... Kircik, L. (2015). Evolving perspectives on the etiology and pathogenesis of acne vulgaris. Journal of Drugs in Dermatology, 14(3), 263-268.

Evolving perspectives on the etiology and pathogenesis of acne vulgaris. / Eichenfield, Lawrence F.; Del Rosso, James Q.; Mancini, Anthony J.; Cook-Bolden, Fran; Gold, Linda Stein; Desai, Seemal; Weiss, Jonathan; Pariser, David; Zeichner, Joshua; Bhatia, Neal; Kircik, Leon.

In: Journal of Drugs in Dermatology, Vol. 14, No. 3, 01.03.2015, p. 263-268.

Research output: Contribution to journalArticle

Eichenfield, LF, Del Rosso, JQ, Mancini, AJ, Cook-Bolden, F, Gold, LS, Desai, S, Weiss, J, Pariser, D, Zeichner, J, Bhatia, N & Kircik, L 2015, 'Evolving perspectives on the etiology and pathogenesis of acne vulgaris', Journal of Drugs in Dermatology, vol. 14, no. 3, pp. 263-268.
Eichenfield LF, Del Rosso JQ, Mancini AJ, Cook-Bolden F, Gold LS, Desai S et al. Evolving perspectives on the etiology and pathogenesis of acne vulgaris. Journal of Drugs in Dermatology. 2015 Mar 1;14(3):263-268.
Eichenfield, Lawrence F. ; Del Rosso, James Q. ; Mancini, Anthony J. ; Cook-Bolden, Fran ; Gold, Linda Stein ; Desai, Seemal ; Weiss, Jonathan ; Pariser, David ; Zeichner, Joshua ; Bhatia, Neal ; Kircik, Leon. / Evolving perspectives on the etiology and pathogenesis of acne vulgaris. In: Journal of Drugs in Dermatology. 2015 ; Vol. 14, No. 3. pp. 263-268.
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