Excess insulin binding to insulin-like growth factor receptors: Proposed mechanism for acanthosis nigricans

Ponciano D Cruz, Joseph A. Hud

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Abstract

Clinical and epidemiologic evidence has shown acanthosis nigricans to be closely related to defective tissue utilization of insulin in a number of previously recognized (e.g., obesity, lipodystrophy, and leprechaunism) as well as recently characterized (e.g., type A and type B syndromes) disorders. This article reviews the relationship of acanthosis nigricans to these insulin-resistant states. It also focuses attention on the possibility that interaction between excessive amounts of circulating insulin with insulin-like growth factor receptors on keratinocytes and dermal fibroblasts leads to the development of acanthosis nigricans.

Original languageEnglish (US)
JournalJournal of Investigative Dermatology
Volume98
Issue number6 SUPPL.
Publication statusPublished - Jun 1992

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ASJC Scopus subject areas

  • Dermatology

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