TY - JOUR
T1 - Exercise Training for Prevention and Treatment of Heart Failure
AU - Kondamudi, Nitin
AU - Haykowsky, Mark
AU - Forman, Daniel E.
AU - Berry, Jarett D.
AU - Pandey, Ambarish
N1 - Publisher Copyright:
© 2017
PY - 2017/6
Y1 - 2017/6
N2 - Heart failure (HF) results in high healthcare costs and burdens for the United States in respects to hospitalizations, therapies, and associated disability. The relative proportion of HF with preserved ejection fraction (HFpEF) compared with HF with reduced ejection fraction (HFrEF) is on the rise; HFpEF has already become the dominant form of HF and it continues to increase. The serious implications of these trends are compounded by a dearth of effective HFpEF therapies. While low physical activity, low cardiorespiratory fitness (CRF), and obesity, are risk factors for HF in general, they particularly predispose to HFpEF. Thus, weight loss and exercise that leads to improved CRF may constitute important opportunities for effective intervention. In this review, we discuss the interplay between physical inactivity, CRF, and obesity in the development of HF, particularly HFpEF, and highlight the current evidence on weight loss and exercise as preventive and therapeutic opportunities.
AB - Heart failure (HF) results in high healthcare costs and burdens for the United States in respects to hospitalizations, therapies, and associated disability. The relative proportion of HF with preserved ejection fraction (HFpEF) compared with HF with reduced ejection fraction (HFrEF) is on the rise; HFpEF has already become the dominant form of HF and it continues to increase. The serious implications of these trends are compounded by a dearth of effective HFpEF therapies. While low physical activity, low cardiorespiratory fitness (CRF), and obesity, are risk factors for HF in general, they particularly predispose to HFpEF. Thus, weight loss and exercise that leads to improved CRF may constitute important opportunities for effective intervention. In this review, we discuss the interplay between physical inactivity, CRF, and obesity in the development of HF, particularly HFpEF, and highlight the current evidence on weight loss and exercise as preventive and therapeutic opportunities.
KW - Cardiorespiratory fitness
KW - Exercise
KW - Heart Failure
KW - Obesity
KW - Weight loss
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U2 - 10.1016/j.pcad.2017.07.001
DO - 10.1016/j.pcad.2017.07.001
M3 - Review article
C2 - 28684221
AN - SCOPUS:85026841752
SN - 0033-0620
VL - 60
SP - 115
EP - 120
JO - Progress in Cardiovascular Diseases
JF - Progress in Cardiovascular Diseases
IS - 1
ER -