Expanding role of ubiquitination in NF-κB signaling

Siqi Liu, Zhijian J. Chen

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-κB.

Original languageEnglish (US)
Pages (from-to)6-21
Number of pages16
JournalCell Research
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 2011

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Keywords

  • IKK
  • NF-κB
  • TAK1
  • TRAFs
  • ubiquitin

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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