Expanding the role of surgical therapy for colorectal liver metastases

Michael A. Choti

Research output: Contribution to journalArticle

Abstract

Management of patients with colorectal metastases to the liver often requires complex multidisciplinary care. Improved short-term and long-term outcomes with hepatic resection have resulted in an increasing aggressive surgical approach for many of these patients. Even with more contemporary definition of resectability, however, most patients may not be initial candidates for resection. The use of other preoperative systemic and liver-directed therapies offers the opportunity to expand the number of patients who may be candidates for curative-intent strategies. Systemic therapies can achieve responses which are capable of downsizing unresectable disease to a resectable status. Local therapies can also be used in a similar way. Yet, the optimal application and timing of these multimodality approaches to expand the role of surgical therapy remain controversial.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalCurrent Colorectal Cancer Reports
Volume8
Issue number2
DOIs
StatePublished - Jun 2012

Fingerprint

Neoplasm Metastasis
Liver
Therapeutics

Keywords

  • Ablation
  • Colorectal liver metastases
  • Conversion chemotherapy
  • DEBIRI
  • Hepatectomy
  • Hepatic metastasis
  • Liver resection
  • Metastasis
  • Portal vein embolization
  • RFA
  • Stereotactic radiation therapy
  • Ytrium-90

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Hepatology

Cite this

Expanding the role of surgical therapy for colorectal liver metastases. / Choti, Michael A.

In: Current Colorectal Cancer Reports, Vol. 8, No. 2, 06.2012, p. 138-142.

Research output: Contribution to journalArticle

@article{44080c01b0754f82bc9c9ce07beec1b9,
title = "Expanding the role of surgical therapy for colorectal liver metastases",
abstract = "Management of patients with colorectal metastases to the liver often requires complex multidisciplinary care. Improved short-term and long-term outcomes with hepatic resection have resulted in an increasing aggressive surgical approach for many of these patients. Even with more contemporary definition of resectability, however, most patients may not be initial candidates for resection. The use of other preoperative systemic and liver-directed therapies offers the opportunity to expand the number of patients who may be candidates for curative-intent strategies. Systemic therapies can achieve responses which are capable of downsizing unresectable disease to a resectable status. Local therapies can also be used in a similar way. Yet, the optimal application and timing of these multimodality approaches to expand the role of surgical therapy remain controversial.",
keywords = "Ablation, Colorectal liver metastases, Conversion chemotherapy, DEBIRI, Hepatectomy, Hepatic metastasis, Liver resection, Metastasis, Portal vein embolization, RFA, Stereotactic radiation therapy, Ytrium-90",
author = "Choti, {Michael A.}",
year = "2012",
month = "6",
doi = "10.1007/s11888-012-0126-5",
language = "English (US)",
volume = "8",
pages = "138--142",
journal = "Current Colorectal Cancer Reports",
issn = "1556-3790",
publisher = "Springer Science + Business Media",
number = "2",

}

TY - JOUR

T1 - Expanding the role of surgical therapy for colorectal liver metastases

AU - Choti, Michael A.

PY - 2012/6

Y1 - 2012/6

N2 - Management of patients with colorectal metastases to the liver often requires complex multidisciplinary care. Improved short-term and long-term outcomes with hepatic resection have resulted in an increasing aggressive surgical approach for many of these patients. Even with more contemporary definition of resectability, however, most patients may not be initial candidates for resection. The use of other preoperative systemic and liver-directed therapies offers the opportunity to expand the number of patients who may be candidates for curative-intent strategies. Systemic therapies can achieve responses which are capable of downsizing unresectable disease to a resectable status. Local therapies can also be used in a similar way. Yet, the optimal application and timing of these multimodality approaches to expand the role of surgical therapy remain controversial.

AB - Management of patients with colorectal metastases to the liver often requires complex multidisciplinary care. Improved short-term and long-term outcomes with hepatic resection have resulted in an increasing aggressive surgical approach for many of these patients. Even with more contemporary definition of resectability, however, most patients may not be initial candidates for resection. The use of other preoperative systemic and liver-directed therapies offers the opportunity to expand the number of patients who may be candidates for curative-intent strategies. Systemic therapies can achieve responses which are capable of downsizing unresectable disease to a resectable status. Local therapies can also be used in a similar way. Yet, the optimal application and timing of these multimodality approaches to expand the role of surgical therapy remain controversial.

KW - Ablation

KW - Colorectal liver metastases

KW - Conversion chemotherapy

KW - DEBIRI

KW - Hepatectomy

KW - Hepatic metastasis

KW - Liver resection

KW - Metastasis

KW - Portal vein embolization

KW - RFA

KW - Stereotactic radiation therapy

KW - Ytrium-90

UR - http://www.scopus.com/inward/record.url?scp=84869135846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869135846&partnerID=8YFLogxK

U2 - 10.1007/s11888-012-0126-5

DO - 10.1007/s11888-012-0126-5

M3 - Article

AN - SCOPUS:84869135846

VL - 8

SP - 138

EP - 142

JO - Current Colorectal Cancer Reports

JF - Current Colorectal Cancer Reports

SN - 1556-3790

IS - 2

ER -