Experimental radioisotope irradiation of renal allografts in dogs

Frederick J. Bonte, Paul C. Peters, Donald Johnson, Watts R. Webb, Bernie A. Stembridge

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Abstract

Rejection of a canine renal allograft is accompanied by infiltration of the graft with lymphocytes and plasmacytes. External beam irradiation of the graft at intervals after transplantation has been employed to lower the population of these invading cells, and, in several laboratories, has been found to prolong host and graft survival. Described herein is a series of experiments in which chronic, low-dose irradiation of canine renal allograft was attempted by causing Mercury-203 to be deposited in graft renal tubular epithelium. Graft and host survivals were prolonged beyond control values for this laboratory in a few animals, but the general technique is not as yet adaptable to the human renal-transplantation problem.

Original languageEnglish (US)
Pages (from-to)689-695
Number of pages7
JournalThe International Journal Of Applied Radiation And Isotopes
Volume18
Issue number10
Publication statusPublished - Oct 1967

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ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Nuclear Energy and Engineering

Cite this

Bonte, F. J., Peters, P. C., Johnson, D., Webb, W. R., & Stembridge, B. A. (1967). Experimental radioisotope irradiation of renal allografts in dogs. The International Journal Of Applied Radiation And Isotopes, 18(10), 689-695.