Experimental validation of a three-dimensional linear system model for breast tomosynthesis

Bo Zhao, Jun Zhou, Yue Houng Hu, Thomas Mertelmeier, Jasmina Ludwig, Wei Zhao

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

A three-dimensional (3D) linear model for digital breast tomosynthesis (DBT) was developed to investigate the effects of different imaging system parameters on the reconstructed image quality. In the present work, experimental validation of the model was performed on a prototype DBT system equipped with an amorphous selenium (a-Se) digital mammography detector and filtered backprojection (FBP) reconstruction methods. The detector can be operated in either full resolution with 85 μm pixel size or 2×1 pixel binning mode to reduce acquisition time. Twenty-five projection images were acquired with a nominal angular range of ±20°. The images were reconstructed using a slice thickness of 1 mm with 0.085×0.085 mm in-plane pixel dimension. The imaging performance was characterized by spatial frequency-dependent parameters including a 3D noise power spectrum (NPS) and in-plane modulation transfer function (MTF). Scatter-free uniform x-ray images were acquired at four different exposure levels for noise analysis. An aluminum (Al) edge phantom with 0.2 mm thickness was imaged to measure the in-plane presampling MTF. The measured in-plane MTF and 3D NPS were both in good agreement with the model. The dependence of DBT image quality on reconstruction filters was investigated. It was found that the slice thickness (ST) filter, a Hanning window to limit the high-frequency components in the slice thickness direction, reduces noise aliasing and improves 3D DQE. An ACR phantom was imaged to investigate the effects of angular range and detector operational modes on reconstructed image quality. It was found that increasing the angular range improves the MTF at low frequencies, resulting in better detection of large-area, low-contrast mass lesions in the phantom. There is a trade-off between noise and resolution for pixel binning and full resolution modes, and the choice of detector mode will depend on radiation dose and the targeted lesion.

Original languageEnglish (US)
Pages (from-to)240-251
Number of pages12
JournalMedical Physics
Volume36
Issue number1
DOIs
StatePublished - 2009

Fingerprint

Mammography
Linear Models
Breast
Noise
Selenium
Aluminum
Theoretical Models
X-Rays
Radiation

Keywords

  • Amorphous selenium detector
  • Breast tomosynthesis
  • MTF
  • NPS
  • Pixel binning

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Experimental validation of a three-dimensional linear system model for breast tomosynthesis. / Zhao, Bo; Zhou, Jun; Hu, Yue Houng; Mertelmeier, Thomas; Ludwig, Jasmina; Zhao, Wei.

In: Medical Physics, Vol. 36, No. 1, 2009, p. 240-251.

Research output: Contribution to journalArticle

Zhao, Bo ; Zhou, Jun ; Hu, Yue Houng ; Mertelmeier, Thomas ; Ludwig, Jasmina ; Zhao, Wei. / Experimental validation of a three-dimensional linear system model for breast tomosynthesis. In: Medical Physics. 2009 ; Vol. 36, No. 1. pp. 240-251.
@article{02169014fa5e43c8a9f04b67269abf98,
title = "Experimental validation of a three-dimensional linear system model for breast tomosynthesis",
abstract = "A three-dimensional (3D) linear model for digital breast tomosynthesis (DBT) was developed to investigate the effects of different imaging system parameters on the reconstructed image quality. In the present work, experimental validation of the model was performed on a prototype DBT system equipped with an amorphous selenium (a-Se) digital mammography detector and filtered backprojection (FBP) reconstruction methods. The detector can be operated in either full resolution with 85 μm pixel size or 2×1 pixel binning mode to reduce acquisition time. Twenty-five projection images were acquired with a nominal angular range of ±20°. The images were reconstructed using a slice thickness of 1 mm with 0.085×0.085 mm in-plane pixel dimension. The imaging performance was characterized by spatial frequency-dependent parameters including a 3D noise power spectrum (NPS) and in-plane modulation transfer function (MTF). Scatter-free uniform x-ray images were acquired at four different exposure levels for noise analysis. An aluminum (Al) edge phantom with 0.2 mm thickness was imaged to measure the in-plane presampling MTF. The measured in-plane MTF and 3D NPS were both in good agreement with the model. The dependence of DBT image quality on reconstruction filters was investigated. It was found that the slice thickness (ST) filter, a Hanning window to limit the high-frequency components in the slice thickness direction, reduces noise aliasing and improves 3D DQE. An ACR phantom was imaged to investigate the effects of angular range and detector operational modes on reconstructed image quality. It was found that increasing the angular range improves the MTF at low frequencies, resulting in better detection of large-area, low-contrast mass lesions in the phantom. There is a trade-off between noise and resolution for pixel binning and full resolution modes, and the choice of detector mode will depend on radiation dose and the targeted lesion.",
keywords = "Amorphous selenium detector, Breast tomosynthesis, MTF, NPS, Pixel binning",
author = "Bo Zhao and Jun Zhou and Hu, {Yue Houng} and Thomas Mertelmeier and Jasmina Ludwig and Wei Zhao",
year = "2009",
doi = "10.1118/1.3040178",
language = "English (US)",
volume = "36",
pages = "240--251",
journal = "Medical Physics",
issn = "0094-2405",
publisher = "AAPM - American Association of Physicists in Medicine",
number = "1",

}

TY - JOUR

T1 - Experimental validation of a three-dimensional linear system model for breast tomosynthesis

AU - Zhao, Bo

AU - Zhou, Jun

AU - Hu, Yue Houng

AU - Mertelmeier, Thomas

AU - Ludwig, Jasmina

AU - Zhao, Wei

PY - 2009

Y1 - 2009

N2 - A three-dimensional (3D) linear model for digital breast tomosynthesis (DBT) was developed to investigate the effects of different imaging system parameters on the reconstructed image quality. In the present work, experimental validation of the model was performed on a prototype DBT system equipped with an amorphous selenium (a-Se) digital mammography detector and filtered backprojection (FBP) reconstruction methods. The detector can be operated in either full resolution with 85 μm pixel size or 2×1 pixel binning mode to reduce acquisition time. Twenty-five projection images were acquired with a nominal angular range of ±20°. The images were reconstructed using a slice thickness of 1 mm with 0.085×0.085 mm in-plane pixel dimension. The imaging performance was characterized by spatial frequency-dependent parameters including a 3D noise power spectrum (NPS) and in-plane modulation transfer function (MTF). Scatter-free uniform x-ray images were acquired at four different exposure levels for noise analysis. An aluminum (Al) edge phantom with 0.2 mm thickness was imaged to measure the in-plane presampling MTF. The measured in-plane MTF and 3D NPS were both in good agreement with the model. The dependence of DBT image quality on reconstruction filters was investigated. It was found that the slice thickness (ST) filter, a Hanning window to limit the high-frequency components in the slice thickness direction, reduces noise aliasing and improves 3D DQE. An ACR phantom was imaged to investigate the effects of angular range and detector operational modes on reconstructed image quality. It was found that increasing the angular range improves the MTF at low frequencies, resulting in better detection of large-area, low-contrast mass lesions in the phantom. There is a trade-off between noise and resolution for pixel binning and full resolution modes, and the choice of detector mode will depend on radiation dose and the targeted lesion.

AB - A three-dimensional (3D) linear model for digital breast tomosynthesis (DBT) was developed to investigate the effects of different imaging system parameters on the reconstructed image quality. In the present work, experimental validation of the model was performed on a prototype DBT system equipped with an amorphous selenium (a-Se) digital mammography detector and filtered backprojection (FBP) reconstruction methods. The detector can be operated in either full resolution with 85 μm pixel size or 2×1 pixel binning mode to reduce acquisition time. Twenty-five projection images were acquired with a nominal angular range of ±20°. The images were reconstructed using a slice thickness of 1 mm with 0.085×0.085 mm in-plane pixel dimension. The imaging performance was characterized by spatial frequency-dependent parameters including a 3D noise power spectrum (NPS) and in-plane modulation transfer function (MTF). Scatter-free uniform x-ray images were acquired at four different exposure levels for noise analysis. An aluminum (Al) edge phantom with 0.2 mm thickness was imaged to measure the in-plane presampling MTF. The measured in-plane MTF and 3D NPS were both in good agreement with the model. The dependence of DBT image quality on reconstruction filters was investigated. It was found that the slice thickness (ST) filter, a Hanning window to limit the high-frequency components in the slice thickness direction, reduces noise aliasing and improves 3D DQE. An ACR phantom was imaged to investigate the effects of angular range and detector operational modes on reconstructed image quality. It was found that increasing the angular range improves the MTF at low frequencies, resulting in better detection of large-area, low-contrast mass lesions in the phantom. There is a trade-off between noise and resolution for pixel binning and full resolution modes, and the choice of detector mode will depend on radiation dose and the targeted lesion.

KW - Amorphous selenium detector

KW - Breast tomosynthesis

KW - MTF

KW - NPS

KW - Pixel binning

UR - http://www.scopus.com/inward/record.url?scp=58149136863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149136863&partnerID=8YFLogxK

U2 - 10.1118/1.3040178

DO - 10.1118/1.3040178

M3 - Article

VL - 36

SP - 240

EP - 251

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 1

ER -