Explaining how brain stimulation can evoke memories

Joshua Jacobs, Bradley Lega, Christopher Anderson

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An unexplained phenomenon in neuroscience is the discovery that electrical stimulation in temporal neo cortex can cause neurosurgical patients to spontaneously experience memory retrieval. Here we provide the first detailed examination of the neural basis of stimulation-induced memory retrieval by probing brain activity in a patient who reliably recalled memories of his high school (HS) after stimulation at a site in his left temporal lobe. After stimulation, this patient performed a customized memory task in which he was prompted to retrieve information from HS and non-HS topics. At the one site where stimulation evoked HS memories, remembering HS information caused a distinctive pattern of neural activity compared with retrieving non-HS information. Together, these findings suggest that the patient had a cluster of neurons in his temporal lobe that help represent the "high school-ness" of the current cognitive state. We believe that stimulation here evoked HS memories because it altered local neural activity in a way that partially mimicked the normal brain state for HS memories. More broadly, our findings suggest that brain stimulation can evoke memories by recreating neural patterns from normal cognition.

Original languageEnglish (US)
Pages (from-to)553-563
Number of pages11
JournalJournal of Cognitive Neuroscience
Volume24
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

brain
Brain
school
Temporal Lobe
Brain Stimulation
High School
Stimulation
Neurosciences
neurosciences
Cognition
Electric Stimulation
cognition
Neurons
examination
cause
experience
Memory Retrieval

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Language and Linguistics
  • Linguistics and Language

Cite this

Explaining how brain stimulation can evoke memories. / Jacobs, Joshua; Lega, Bradley; Anderson, Christopher.

In: Journal of Cognitive Neuroscience, Vol. 24, No. 3, 03.2012, p. 553-563.

Research output: Contribution to journalArticle

Jacobs, Joshua ; Lega, Bradley ; Anderson, Christopher. / Explaining how brain stimulation can evoke memories. In: Journal of Cognitive Neuroscience. 2012 ; Vol. 24, No. 3. pp. 553-563.
@article{5d835c36d3834147bea25c8829c28556,
title = "Explaining how brain stimulation can evoke memories",
abstract = "An unexplained phenomenon in neuroscience is the discovery that electrical stimulation in temporal neo cortex can cause neurosurgical patients to spontaneously experience memory retrieval. Here we provide the first detailed examination of the neural basis of stimulation-induced memory retrieval by probing brain activity in a patient who reliably recalled memories of his high school (HS) after stimulation at a site in his left temporal lobe. After stimulation, this patient performed a customized memory task in which he was prompted to retrieve information from HS and non-HS topics. At the one site where stimulation evoked HS memories, remembering HS information caused a distinctive pattern of neural activity compared with retrieving non-HS information. Together, these findings suggest that the patient had a cluster of neurons in his temporal lobe that help represent the {"}high school-ness{"} of the current cognitive state. We believe that stimulation here evoked HS memories because it altered local neural activity in a way that partially mimicked the normal brain state for HS memories. More broadly, our findings suggest that brain stimulation can evoke memories by recreating neural patterns from normal cognition.",
author = "Joshua Jacobs and Bradley Lega and Christopher Anderson",
year = "2012",
month = "3",
doi = "10.1162/jocn_a_00170",
language = "English (US)",
volume = "24",
pages = "553--563",
journal = "Journal of Cognitive Neuroscience",
issn = "0898-929X",
publisher = "MIT Press Journals",
number = "3",

}

TY - JOUR

T1 - Explaining how brain stimulation can evoke memories

AU - Jacobs, Joshua

AU - Lega, Bradley

AU - Anderson, Christopher

PY - 2012/3

Y1 - 2012/3

N2 - An unexplained phenomenon in neuroscience is the discovery that electrical stimulation in temporal neo cortex can cause neurosurgical patients to spontaneously experience memory retrieval. Here we provide the first detailed examination of the neural basis of stimulation-induced memory retrieval by probing brain activity in a patient who reliably recalled memories of his high school (HS) after stimulation at a site in his left temporal lobe. After stimulation, this patient performed a customized memory task in which he was prompted to retrieve information from HS and non-HS topics. At the one site where stimulation evoked HS memories, remembering HS information caused a distinctive pattern of neural activity compared with retrieving non-HS information. Together, these findings suggest that the patient had a cluster of neurons in his temporal lobe that help represent the "high school-ness" of the current cognitive state. We believe that stimulation here evoked HS memories because it altered local neural activity in a way that partially mimicked the normal brain state for HS memories. More broadly, our findings suggest that brain stimulation can evoke memories by recreating neural patterns from normal cognition.

AB - An unexplained phenomenon in neuroscience is the discovery that electrical stimulation in temporal neo cortex can cause neurosurgical patients to spontaneously experience memory retrieval. Here we provide the first detailed examination of the neural basis of stimulation-induced memory retrieval by probing brain activity in a patient who reliably recalled memories of his high school (HS) after stimulation at a site in his left temporal lobe. After stimulation, this patient performed a customized memory task in which he was prompted to retrieve information from HS and non-HS topics. At the one site where stimulation evoked HS memories, remembering HS information caused a distinctive pattern of neural activity compared with retrieving non-HS information. Together, these findings suggest that the patient had a cluster of neurons in his temporal lobe that help represent the "high school-ness" of the current cognitive state. We believe that stimulation here evoked HS memories because it altered local neural activity in a way that partially mimicked the normal brain state for HS memories. More broadly, our findings suggest that brain stimulation can evoke memories by recreating neural patterns from normal cognition.

UR - http://www.scopus.com/inward/record.url?scp=84856321528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856321528&partnerID=8YFLogxK

U2 - 10.1162/jocn_a_00170

DO - 10.1162/jocn_a_00170

M3 - Article

C2 - 22098266

AN - SCOPUS:84856321528

VL - 24

SP - 553

EP - 563

JO - Journal of Cognitive Neuroscience

JF - Journal of Cognitive Neuroscience

SN - 0898-929X

IS - 3

ER -