Exploratory associations with Tumor Necrosis Factor-α, disinhibition and suicidal endorsement after traumatic brain injury

S. B. Juengst, R. G. Kumar, P. M. Arenth, A. K. Wagner

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Purpose: To examine the relationship of Tumor Necrosis Factor (TNF)-α to disinhibition and suicidal endorsement after traumatic brain injury (TBI). Participants: Adults with moderate to severe TBI (acute serum levels: n=. 48, n=. 543 samples; acute CSF levels: n=. 37, n=. 389 samples; chronic serum levels: n=. 48, n=. 326 samples). Main measures: TNFα levels (CSF, Serum) from time of injury to 12. months post-injury; Frontal Systems Behavior Scale - Disinhibition Subscale at 6 and 12. months post-injury; Patient Health Questionnaire at 6 and 12. months post-injury. Results: Participants with TBI had significantly higher CSF and serum TNFα levels than healthy controls (. p<. 0.05). Acute and chronic serum TNFα was significantly associated with disinhibition at 6. months post-injury (. p=. 0.009, p=. 0.029 respectively), and 6. month disinhibition was associated with suicidal endorsement at both 6 and 12. months (. p=. 0.045, p=. 0.033 respectively) and disinhibition at 12. months post-injury (. p<. 0.001). Conclusion: These preliminary data suggest a biological to behavioral pathway of suicidality after TBI, from TNFα to disinhibition to suicidal endorsement. Future investigation is warranted to validate these findings and clarify what biological mechanisms might underlie these relationships.

Original languageEnglish (US)
Pages (from-to)134-143
Number of pages10
JournalBrain, Behavior, and Immunity
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Tumor Necrosis Factor-alpha
Wounds and Injuries
Serum
Traumatic Brain Injury
Health

Keywords

  • Brain injury
  • Depression
  • Disinhibition
  • Impulsivity
  • Inflammation
  • Suicide
  • Tumor Necrosis Factor-Alpha

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

Cite this

Exploratory associations with Tumor Necrosis Factor-α, disinhibition and suicidal endorsement after traumatic brain injury. / Juengst, S. B.; Kumar, R. G.; Arenth, P. M.; Wagner, A. K.

In: Brain, Behavior, and Immunity, Vol. 41, No. 1, 01.01.2014, p. 134-143.

Research output: Contribution to journalArticle

@article{02f8c27a22644554bbfbb35d57232f05,
title = "Exploratory associations with Tumor Necrosis Factor-α, disinhibition and suicidal endorsement after traumatic brain injury",
abstract = "Purpose: To examine the relationship of Tumor Necrosis Factor (TNF)-α to disinhibition and suicidal endorsement after traumatic brain injury (TBI). Participants: Adults with moderate to severe TBI (acute serum levels: n=. 48, n=. 543 samples; acute CSF levels: n=. 37, n=. 389 samples; chronic serum levels: n=. 48, n=. 326 samples). Main measures: TNFα levels (CSF, Serum) from time of injury to 12. months post-injury; Frontal Systems Behavior Scale - Disinhibition Subscale at 6 and 12. months post-injury; Patient Health Questionnaire at 6 and 12. months post-injury. Results: Participants with TBI had significantly higher CSF and serum TNFα levels than healthy controls (. p<. 0.05). Acute and chronic serum TNFα was significantly associated with disinhibition at 6. months post-injury (. p=. 0.009, p=. 0.029 respectively), and 6. month disinhibition was associated with suicidal endorsement at both 6 and 12. months (. p=. 0.045, p=. 0.033 respectively) and disinhibition at 12. months post-injury (. p<. 0.001). Conclusion: These preliminary data suggest a biological to behavioral pathway of suicidality after TBI, from TNFα to disinhibition to suicidal endorsement. Future investigation is warranted to validate these findings and clarify what biological mechanisms might underlie these relationships.",
keywords = "Brain injury, Depression, Disinhibition, Impulsivity, Inflammation, Suicide, Tumor Necrosis Factor-Alpha",
author = "Juengst, {S. B.} and Kumar, {R. G.} and Arenth, {P. M.} and Wagner, {A. K.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.bbi.2014.05.020",
language = "English (US)",
volume = "41",
pages = "134--143",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Exploratory associations with Tumor Necrosis Factor-α, disinhibition and suicidal endorsement after traumatic brain injury

AU - Juengst, S. B.

AU - Kumar, R. G.

AU - Arenth, P. M.

AU - Wagner, A. K.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: To examine the relationship of Tumor Necrosis Factor (TNF)-α to disinhibition and suicidal endorsement after traumatic brain injury (TBI). Participants: Adults with moderate to severe TBI (acute serum levels: n=. 48, n=. 543 samples; acute CSF levels: n=. 37, n=. 389 samples; chronic serum levels: n=. 48, n=. 326 samples). Main measures: TNFα levels (CSF, Serum) from time of injury to 12. months post-injury; Frontal Systems Behavior Scale - Disinhibition Subscale at 6 and 12. months post-injury; Patient Health Questionnaire at 6 and 12. months post-injury. Results: Participants with TBI had significantly higher CSF and serum TNFα levels than healthy controls (. p<. 0.05). Acute and chronic serum TNFα was significantly associated with disinhibition at 6. months post-injury (. p=. 0.009, p=. 0.029 respectively), and 6. month disinhibition was associated with suicidal endorsement at both 6 and 12. months (. p=. 0.045, p=. 0.033 respectively) and disinhibition at 12. months post-injury (. p<. 0.001). Conclusion: These preliminary data suggest a biological to behavioral pathway of suicidality after TBI, from TNFα to disinhibition to suicidal endorsement. Future investigation is warranted to validate these findings and clarify what biological mechanisms might underlie these relationships.

AB - Purpose: To examine the relationship of Tumor Necrosis Factor (TNF)-α to disinhibition and suicidal endorsement after traumatic brain injury (TBI). Participants: Adults with moderate to severe TBI (acute serum levels: n=. 48, n=. 543 samples; acute CSF levels: n=. 37, n=. 389 samples; chronic serum levels: n=. 48, n=. 326 samples). Main measures: TNFα levels (CSF, Serum) from time of injury to 12. months post-injury; Frontal Systems Behavior Scale - Disinhibition Subscale at 6 and 12. months post-injury; Patient Health Questionnaire at 6 and 12. months post-injury. Results: Participants with TBI had significantly higher CSF and serum TNFα levels than healthy controls (. p<. 0.05). Acute and chronic serum TNFα was significantly associated with disinhibition at 6. months post-injury (. p=. 0.009, p=. 0.029 respectively), and 6. month disinhibition was associated with suicidal endorsement at both 6 and 12. months (. p=. 0.045, p=. 0.033 respectively) and disinhibition at 12. months post-injury (. p<. 0.001). Conclusion: These preliminary data suggest a biological to behavioral pathway of suicidality after TBI, from TNFα to disinhibition to suicidal endorsement. Future investigation is warranted to validate these findings and clarify what biological mechanisms might underlie these relationships.

KW - Brain injury

KW - Depression

KW - Disinhibition

KW - Impulsivity

KW - Inflammation

KW - Suicide

KW - Tumor Necrosis Factor-Alpha

UR - http://www.scopus.com/inward/record.url?scp=84924076838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924076838&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2014.05.020

DO - 10.1016/j.bbi.2014.05.020

M3 - Article

C2 - 24928066

AN - SCOPUS:84924076838

VL - 41

SP - 134

EP - 143

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

IS - 1

ER -