Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: Correlations with the degree of dysplasia

Z. P. Pavelic, L. Pavelic, K. Pavelic, R. M. Genta, M. B. Ray, G. Dvornik, M. Scukanec-Spoljar, J. S. Peacock

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Sections of tubular adenomas (n=40), ulcertive colitis (n=97) and hyperplastic polyps (n=31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scatterred weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.

Original languageEnglish (US)
Pages (from-to)1671-1675
Number of pages5
JournalAnticancer Research
Volume11
Issue number5
StatePublished - Dec 1 1991

Keywords

  • Carcinoembryonic antigen
  • Dysplasia degree
  • Hyperplastic polyps
  • Tubular adenoma
  • Ulcerative colitis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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