Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: Correlations with the degree of dysplasia

Z. P. Pavelic, L. Pavelic, K. Pavelic, R. M. Genta, M. B. Ray, G. Dvornik, M. Scukanec-Spoljar, J. S. Peacock

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sections of tubular adenomas (n=40), ulcertive colitis (n=97) and hyperplastic polyps (n=31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scatterred weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.

Original languageEnglish (US)
Pages (from-to)1671-1675
Number of pages5
JournalAnticancer Research
Volume11
Issue number5
StatePublished - 1991

Fingerprint

Carcinoembryonic Antigen
Polyps
Ulcerative Colitis
Adenoma
Staining and Labeling
Colitis

Keywords

  • Carcinoembryonic antigen
  • Dysplasia degree
  • Hyperplastic polyps
  • Tubular adenoma
  • Ulcerative colitis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pavelic, Z. P., Pavelic, L., Pavelic, K., Genta, R. M., Ray, M. B., Dvornik, G., ... Peacock, J. S. (1991). Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: Correlations with the degree of dysplasia. Anticancer Research, 11(5), 1671-1675.

Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps : Correlations with the degree of dysplasia. / Pavelic, Z. P.; Pavelic, L.; Pavelic, K.; Genta, R. M.; Ray, M. B.; Dvornik, G.; Scukanec-Spoljar, M.; Peacock, J. S.

In: Anticancer Research, Vol. 11, No. 5, 1991, p. 1671-1675.

Research output: Contribution to journalArticle

Pavelic, ZP, Pavelic, L, Pavelic, K, Genta, RM, Ray, MB, Dvornik, G, Scukanec-Spoljar, M & Peacock, JS 1991, 'Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: Correlations with the degree of dysplasia', Anticancer Research, vol. 11, no. 5, pp. 1671-1675.
Pavelic, Z. P. ; Pavelic, L. ; Pavelic, K. ; Genta, R. M. ; Ray, M. B. ; Dvornik, G. ; Scukanec-Spoljar, M. ; Peacock, J. S. / Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps : Correlations with the degree of dysplasia. In: Anticancer Research. 1991 ; Vol. 11, No. 5. pp. 1671-1675.
@article{023b3800d84e400296af1db7559846af,
title = "Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: Correlations with the degree of dysplasia",
abstract = "Sections of tubular adenomas (n=40), ulcertive colitis (n=97) and hyperplastic polyps (n=31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scatterred weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.",
keywords = "Carcinoembryonic antigen, Dysplasia degree, Hyperplastic polyps, Tubular adenoma, Ulcerative colitis",
author = "Pavelic, {Z. P.} and L. Pavelic and K. Pavelic and Genta, {R. M.} and Ray, {M. B.} and G. Dvornik and M. Scukanec-Spoljar and Peacock, {J. S.}",
year = "1991",
language = "English (US)",
volume = "11",
pages = "1671--1675",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",

}

TY - JOUR

T1 - Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps

T2 - Correlations with the degree of dysplasia

AU - Pavelic, Z. P.

AU - Pavelic, L.

AU - Pavelic, K.

AU - Genta, R. M.

AU - Ray, M. B.

AU - Dvornik, G.

AU - Scukanec-Spoljar, M.

AU - Peacock, J. S.

PY - 1991

Y1 - 1991

N2 - Sections of tubular adenomas (n=40), ulcertive colitis (n=97) and hyperplastic polyps (n=31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scatterred weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.

AB - Sections of tubular adenomas (n=40), ulcertive colitis (n=97) and hyperplastic polyps (n=31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scatterred weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.

KW - Carcinoembryonic antigen

KW - Dysplasia degree

KW - Hyperplastic polyps

KW - Tubular adenoma

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=0026326749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026326749&partnerID=8YFLogxK

M3 - Article

C2 - 1768036

AN - SCOPUS:0026326749

VL - 11

SP - 1671

EP - 1675

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 5

ER -