Expression of p25 impairs contextual learning but not latent inhibition in mice

Keiko Mizuno, Florian Plattner, K. Peter Giese

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The cyclin-dependent kinase 5 activator p25, which is derived from cleavage of p35, is thought to be formed in the brain of patients with Alzheimer's disease and schizophrenia. Female, but not male, transgenic mice expressing low levels of p25 have enhanced hippocampal long-term potentiation and improved spatial learning, raising the hypothesis that p25 may compensate for early learning deficits in Alzheimer's disease in a sex-dependent manner. Here, we show that low levels of p25 do not alter latent inhibition, a phenomenon that is impaired in patients with schizophrenia. We also demonstrate that contextual fear conditioning is impaired in female, but not in male, p25 transgenic mice. Thus, low levels of p25 are not always beneficial for learning as was previously hypothesized.

Original languageEnglish (US)
Pages (from-to)1903-1905
Number of pages3
JournalNeuroReport
Volume17
Issue number18
DOIs
StatePublished - Dec 2006

Fingerprint

Transgenic Mice
Schizophrenia
Alzheimer Disease
Cyclin-Dependent Kinase 5
Learning
Long-Term Potentiation
Fear
Brain
Inhibition (Psychology)
Conditioning (Psychology)
Spatial Learning

Keywords

  • Alzheimer's disease
  • Cdk5
  • Contextual fear conditioning
  • Hippocampus
  • Latent inhibition
  • Memory
  • Mouse
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Expression of p25 impairs contextual learning but not latent inhibition in mice. / Mizuno, Keiko; Plattner, Florian; Peter Giese, K.

In: NeuroReport, Vol. 17, No. 18, 12.2006, p. 1903-1905.

Research output: Contribution to journalArticle

Mizuno, Keiko ; Plattner, Florian ; Peter Giese, K. / Expression of p25 impairs contextual learning but not latent inhibition in mice. In: NeuroReport. 2006 ; Vol. 17, No. 18. pp. 1903-1905.
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