Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A

Ravi R. Thiagarajan, Stephen J. Roth, Steven Margossian, Andrew S. Mackie, Ellis J. Neufeld, Peter C. Laussen, Joseph M. Forbess, Elizabeth D. Blume

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objective: To report the use of extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation in a patient with hemophilia A and dilated cardiomyopathy. Design: Case report. Interventions and results: During ECMO factor VIII concentrate was administered to maintain a factor VIII level close to 50% of normal control both to decrease the risk of bleeding and to allow standard anticoagulation with heparin. The patient developed an inhibitor to exogenous factor VIII during hospitalization, which was successfully managed with a high-dose continuous infusion of factor VIII during ECMO, the transplant operation, and the postoperative period. Conclusions: We report the successful use of ECMO as a bridge to cardiac transplantation in a patient with hemophilia A and low-level factor VIII inhibitors.

Original languageEnglish (US)
Pages (from-to)985-988
Number of pages4
JournalIntensive Care Medicine
Volume29
Issue number6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Cardiac transplantation
  • Dilated cardiomyopathy
  • Extracorporeal membrane oxygenation
  • Factor VIII inhibitor
  • Hemophilia A

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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    Thiagarajan, R. R., Roth, S. J., Margossian, S., Mackie, A. S., Neufeld, E. J., Laussen, P. C., Forbess, J. M., & Blume, E. D. (2003). Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A. Intensive Care Medicine, 29(6), 985-988. https://doi.org/10.1007/s00134-003-1748-5