Extrahepatic manifestations of hepatitis C infection

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) affects 1.8% of the American population, and approximately 38% of patients with HCV will manifest symptoms of at least 1 extrahepatic manifestation during the illness. Renal disease, neuropathy, lymphoma, and Sj6gren syndrome with or without mixed cryoglobulinemia are all strongly associated with HCV infection. Porphyria cutanea tarda and diabetes have also been linked to HCV. Most extrahepatic manifestations of chronic HCV infection are immunological, and the chronic infection seems to be necessary for their development. The molecular study of the unique way in which the HCV virus interacts with the human immune system is beginning to provide plausible explanations of the pathogenic role of HCV in some of these syndromes, but many pathogenetic links remain completely obscure.

Original languageEnglish (US)
Pages (from-to)135-148
Number of pages14
JournalAmerican Journal of the Medical Sciences
Volume325
Issue number3
DOIs
StatePublished - Mar 1 2003

Fingerprint

Hepatitis C
Hepacivirus
Infection
Virus Diseases
Porphyria Cutanea Tarda
Cryoglobulinemia
Chronic Hepatitis C
Immune System
Lymphoma
Viruses
Kidney
Population

Keywords

  • Cirrhosis
  • Cryoglobulinemia
  • Hepatitis
  • Lymphoma
  • Porphyria

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Extrahepatic manifestations of hepatitis C infection. / Mayo, Marlyn J.

In: American Journal of the Medical Sciences, Vol. 325, No. 3, 01.03.2003, p. 135-148.

Research output: Contribution to journalArticle

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