Extramedullary hematopoiesis in unusual locations in hematologically compromised and noncompromised patients

Prabhakar Rajiah, Riku Hayashi, Thomas W. Bauer, Murali Sundaram

Research output: Contribution to journalArticle

14 Scopus citations


Extramedullary hematopoiesis (EMH) occurs as a compensatory reaction to an underlying hematologic abnormality. EMH is most commonly seen in the liver and spleen but rarely has been reported in other locations, as well. On rare occasions, EMH may mimic a neoplasm in hematologically noncompromised patients. In this report, we present three cases of EMH in unusual locations, two in the presacral soft tissue and one in the synovial lining of the knee joint. The patients with presacral masses had no hematologic abnormality. In all patients with EMH, imaging plays an important role in both localization of the lesion and guidance for the biopsy; when imaging results are correlated with histological findings, the diagnosis of EMH can be confirmed.

Original languageEnglish (US)
Pages (from-to)947-953
Number of pages7
JournalSkeletal Radiology
Issue number7
StatePublished - Jul 1 2011



  • Extramedullary hematopoiesis
  • MRI
  • Presacral
  • Synovial

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this