Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods

Feng Qian, Agata Szymanski, Jinming Gao

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

A compression-heat molding procedure was developed to fabricate poly(D,L-lactide-co-glycolide) (PLGA) controlled release drug delivery devices for the local treatment of tumors. The drug delivery devices were designed in the shape of a cylindrical millirod (1.6-mm diameter, 10-mm length), which allows them to be implanted by a modified 14-gauge tissue biopsy needle into tumor tissues via image-guided interventional procedures. In this study, the proto-type trypan blue-containing PLGA millirods were fabricated under a compression pressure of 4.6 × 106 Pa and different fabrication temperatures for 2 h. The scanning electron microscopy results showed complete polymer annealing for millirods fabricated at 80 and 90°C, while the cross sections of the 60 and 70°C millirods showed incompletely annealed PLGA microspheres and trypan blue powders. The density, flexural modulus, and release properties of the PLGA millirods were also characterized and compared. The average values of the density and flexural modulus of the millirods increased with an increase in fabrication temperature. The flexural modulus values of most PLGA millirods were above 1 × 108 Pa, which provides sufficient stiffness for implantation within the tumor tissue. In addition, a Δcp method was developed to determine the loading density of trypan blue in the PLGA millirods by differential scanning calorimetry. Results from the Δcp measurement showed that trypan blue was homogeneously distributed in the millirod. Release studies in phosphate-buffered saline showed that the release rate decreased for the millirods fabricated at higher temperatures. The times for the release of 50% trypan blue were 5, 25, 25, and 25 h for millirods fabricated at 60, 70, 80, and 90°C, respectively. Millirods fabricated at 90°C had the most reproducible release profiles. The results from this study established compression-heat molding as an effective method to fabricate controlled release PLGA millirods with sufficient mechanical strength and reproducible release profiles for local cancer therapy.

Original languageEnglish (US)
Pages (from-to)512-522
Number of pages11
JournalJournal of Biomedical Materials Research
Volume55
Issue number4
DOIs
StatePublished - Jun 15 2001

Keywords

  • Compression-heat molding
  • Controlled release drug delivery
  • Poly(D,L-lactide-co-glycolide)
  • Polymer characterization

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods'. Together they form a unique fingerprint.

Cite this