Factors Affecting Image Quality and Lesion Evaluability in Breast Diffusion-weighted MRI: Observations from the ECOG-ACRIN Cancer Research Group Multisite Trial (A6702)

Jennifer G. Whisenant, Justin Romanoff, Habib Rahbar, Averi E. Kitsch, Sara M. Harvey, Linda Moy, Wendy B. Demartini, Basak E. Dogan, Wei T. Yang, Lilian C. Wang, Bonnie N. Joe, Lisa J. Wilmes, Nola M. Hylton, Karen Y. Oh, Luminita A. Tudorica, Colleen H. Neal, Dariya I. Malyarenko, Elizabeth S. McDonald, Christopher E. Comstock, Thomas E. YankeelovThomas L. Chenevert, Savannah C. Partridge

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The A6702 multisite trial confirmed that apparent diffusion coefficient (ADC) measures can improve breast MRI accuracy and reduce unnecessary biopsies, but also found that technical issues rendered many lesions non-evaluable on diffusion-weighted imaging (DWI). This secondary analysis investigated factors affecting lesion evaluability and impact on diagnostic performance. Methods: The A6702 protocol was IRB-approved at 10 institutions; participants provided informed consent. In total, 103 women with 142 MRI-detected breast lesions (BI-RADS assessment category 3, 4, or 5) completed the study. DWI was acquired at 1.5T and 3T using a four b-value, echo-planar imaging sequence. Scans were reviewed for multiple quality factors (artifacts, signal-to-noise, misregistration, and fat suppression); lesions were considered non-evaluable if there was low confidence in ADC measurement. Associations of lesion evaluability with imaging and lesion characteristics were determined. Areas under the receiver operating characteristic curves (AUCs) were compared using bootstrapping. Results: Thirty percent (42/142) of lesions were non-evaluable on DWI; 23% (32/142) with image quality issues, 7% (10/142) with conspicuity and/or localization issues. Misregistration was the only factor associated with non-evaluability (P = 0.001). Smaller (≤10 mm) lesions were more commonly non-evaluable than larger lesions (p <0.03), though not significant after multiplicity correction. The AUC for differentiating benign and malignant lesions increased after excluding non-evaluable lesions, from 0.61 (95% CI: 0.50-0.71) to 0.75 (95% CI: 0.65-0.84). Conclusion: Image quality remains a technical challenge in breast DWI, particularly for smaller lesions. Protocol optimization and advanced acquisition and post-processing techniques would help to improve clinical utility.

Original languageEnglish (US)
Pages (from-to)44-56
Number of pages13
JournalJournal of Breast Imaging
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2021

Keywords

  • apparent diffusion coefficient (ADC)
  • artifacts
  • breast magnetic resonance imaging (MRI)
  • diagnostic performance
  • multicenter trial

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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