TY - JOUR
T1 - False-positive sentinel lymph nodes in breast cancer patients caused by benign glandular inclusions
T2 - Report of three cases and review of the literature
AU - Peng, Yan
AU - Ashfaq, Raheela
AU - Ewing, Gene
AU - Leitch, A. Marilyn
AU - Molberg, Kyle H.
PY - 2008/7
Y1 - 2008/7
N2 - We report 3 cases of sentinel lymph nodes (SLNs) containing benign glandular inclusions (BGIs) in patients with breast carcinoma that were initially misdiagnosed as metastatic carcinoma. The first case had an SLN with glandular elements adjacent to a squamous inclusion cyst, the second had an SLN with a single complex gland showing apocrine features, and the third had 2 SLNs, each containing rare glands lined by bland columnar cells and surrounded by thin, fibrous bands. All glandular elements were distinctly different from the corresponding invasive carcinoma. Immunostains for myoepithelial markers revealed smooth muscle myosin reactivity and scattered p63+ nuclei, indicating the presence of myoepithelial cells. Based on morphologic and immunohistochemical findings, a diagnosis of BGIs was established. Our case series report indicates that comparison with the morphologic features of primary breast carcinoma and using immunohistochemical analysis for myoepithelial markers are important ancillary tools in distinguishing BGIs from metastatic carcinoma.
AB - We report 3 cases of sentinel lymph nodes (SLNs) containing benign glandular inclusions (BGIs) in patients with breast carcinoma that were initially misdiagnosed as metastatic carcinoma. The first case had an SLN with glandular elements adjacent to a squamous inclusion cyst, the second had an SLN with a single complex gland showing apocrine features, and the third had 2 SLNs, each containing rare glands lined by bland columnar cells and surrounded by thin, fibrous bands. All glandular elements were distinctly different from the corresponding invasive carcinoma. Immunostains for myoepithelial markers revealed smooth muscle myosin reactivity and scattered p63+ nuclei, indicating the presence of myoepithelial cells. Based on morphologic and immunohistochemical findings, a diagnosis of BGIs was established. Our case series report indicates that comparison with the morphologic features of primary breast carcinoma and using immunohistochemical analysis for myoepithelial markers are important ancillary tools in distinguishing BGIs from metastatic carcinoma.
KW - Axillary sentinel nodes
KW - Benign glandular inclusions
KW - Breast carcinoma
KW - False-positive
KW - Immunostains for myoepithelial markers
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U2 - 10.1309/JVB8QFQNW5HBN7UJ
DO - 10.1309/JVB8QFQNW5HBN7UJ
M3 - Article
C2 - 18550466
AN - SCOPUS:48249131717
SN - 0002-9173
VL - 130
SP - 21
EP - 27
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 1
ER -