Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

Pengyuan Liu, Haris G. Vikis, Daolong Wang, Yan Lu, Yian Wang, Ann G. Schwartz, Susan M. Pinney, Ping Yang, Mariza De Andrade, Gloria M. Petersen, Jonathan S. Wiest, Pamela R. Fain, Adi Gazdar, Colette Gaba, Henry Rothschild, Diptasri Mandal, Teresa Coons, Juwon Lee, Elena Kupert, Daniela SeminaraJohn Minna, Joan E. Bailey-Wilson, Xifeng Wu, Margaret R. Spitz, Timothy Eisen, Richard S. Houlston, Christopher I. Amos, Marshall W. Anderson, Ming You

Research output: Contribution to journalArticle

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Abstract

Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.

Original languageEnglish (US)
Pages (from-to)1326-1330
Number of pages5
JournalJournal of the National Cancer Institute
Volume100
Issue number18
DOIs
StatePublished - Sep 2008

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Lung Neoplasms
Genome-Wide Association Study
Odds Ratio
Confidence Intervals
Internal-External Control
Single Nucleotide Polymorphism
Alleles
DNA
Research
Genes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Liu, P., Vikis, H. G., Wang, D., Lu, Y., Wang, Y., Schwartz, A. G., ... You, M. (2008). Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. Journal of the National Cancer Institute, 100(18), 1326-1330. https://doi.org/10.1093/jnci/djn268

Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. / Liu, Pengyuan; Vikis, Haris G.; Wang, Daolong; Lu, Yan; Wang, Yian; Schwartz, Ann G.; Pinney, Susan M.; Yang, Ping; De Andrade, Mariza; Petersen, Gloria M.; Wiest, Jonathan S.; Fain, Pamela R.; Gazdar, Adi; Gaba, Colette; Rothschild, Henry; Mandal, Diptasri; Coons, Teresa; Lee, Juwon; Kupert, Elena; Seminara, Daniela; Minna, John; Bailey-Wilson, Joan E.; Wu, Xifeng; Spitz, Margaret R.; Eisen, Timothy; Houlston, Richard S.; Amos, Christopher I.; Anderson, Marshall W.; You, Ming.

In: Journal of the National Cancer Institute, Vol. 100, No. 18, 09.2008, p. 1326-1330.

Research output: Contribution to journalArticle

Liu, P, Vikis, HG, Wang, D, Lu, Y, Wang, Y, Schwartz, AG, Pinney, SM, Yang, P, De Andrade, M, Petersen, GM, Wiest, JS, Fain, PR, Gazdar, A, Gaba, C, Rothschild, H, Mandal, D, Coons, T, Lee, J, Kupert, E, Seminara, D, Minna, J, Bailey-Wilson, JE, Wu, X, Spitz, MR, Eisen, T, Houlston, RS, Amos, CI, Anderson, MW & You, M 2008, 'Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer', Journal of the National Cancer Institute, vol. 100, no. 18, pp. 1326-1330. https://doi.org/10.1093/jnci/djn268
Liu, Pengyuan ; Vikis, Haris G. ; Wang, Daolong ; Lu, Yan ; Wang, Yian ; Schwartz, Ann G. ; Pinney, Susan M. ; Yang, Ping ; De Andrade, Mariza ; Petersen, Gloria M. ; Wiest, Jonathan S. ; Fain, Pamela R. ; Gazdar, Adi ; Gaba, Colette ; Rothschild, Henry ; Mandal, Diptasri ; Coons, Teresa ; Lee, Juwon ; Kupert, Elena ; Seminara, Daniela ; Minna, John ; Bailey-Wilson, Joan E. ; Wu, Xifeng ; Spitz, Margaret R. ; Eisen, Timothy ; Houlston, Richard S. ; Amos, Christopher I. ; Anderson, Marshall W. ; You, Ming. / Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. In: Journal of the National Cancer Institute. 2008 ; Vol. 100, No. 18. pp. 1326-1330.
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AU - Liu, Pengyuan

AU - Vikis, Haris G.

AU - Wang, Daolong

AU - Lu, Yan

AU - Wang, Yian

AU - Schwartz, Ann G.

AU - Pinney, Susan M.

AU - Yang, Ping

AU - De Andrade, Mariza

AU - Petersen, Gloria M.

AU - Wiest, Jonathan S.

AU - Fain, Pamela R.

AU - Gazdar, Adi

AU - Gaba, Colette

AU - Rothschild, Henry

AU - Mandal, Diptasri

AU - Coons, Teresa

AU - Lee, Juwon

AU - Kupert, Elena

AU - Seminara, Daniela

AU - Minna, John

AU - Bailey-Wilson, Joan E.

AU - Wu, Xifeng

AU - Spitz, Margaret R.

AU - Eisen, Timothy

AU - Houlston, Richard S.

AU - Amos, Christopher I.

AU - Anderson, Marshall W.

AU - You, Ming

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N2 - Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.

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