Fatal misonidazole‐induced encephalopathy. An RTOG case report

Larry E. Kun; Khang‐Cheng ‐C Ho; John E. Moulder

doi:10.1002/1097-0142(19820201)49:3<423::AID-CNCR2820490305>3.0.CO;2-L

Fatal misonidazole‐induced encephalopathy. An RTOG case report

Larry E. Kun, Khang‐Cheng ‐C Ho, John E. Moulder

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Abstract

A case of fatal encephalopathy following administration of misonidazole (MISO) is reported. Anorexia and dehydration preceded signs of encephalopathy after a cumulative dose of 18 g (11 g/m²) of MISO in five weekly doses. Serum MISO levels four hours after weekly administrations were markedly elevated. Postmortem examination revealed focal cortical neuronal necrosis and hemorrhage with focal demyelination. The possible relationship of dehydration or altered drug metabolism to the development of MISO central nervous system toxicity is noted.

Original language	English (US)
Pages (from-to)	423-426
Number of pages	4
Journal	Cancer
Volume	49
Issue number	3
DOIs	https://doi.org/10.1002/1097-0142(19820201)49:3<423::AID-CNCR2820490305>3.0.CO;2-L
State	Published - Feb 1 1982

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19820201)49:3<423::AID-CNCR2820490305>3.0.CO;2-L

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abstract = "A case of fatal encephalopathy following administration of misonidazole (MISO) is reported. Anorexia and dehydration preceded signs of encephalopathy after a cumulative dose of 18 g (11 g/m2) of MISO in five weekly doses. Serum MISO levels four hours after weekly administrations were markedly elevated. Postmortem examination revealed focal cortical neuronal necrosis and hemorrhage with focal demyelination. The possible relationship of dehydration or altered drug metabolism to the development of MISO central nervous system toxicity is noted.",

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N2 - A case of fatal encephalopathy following administration of misonidazole (MISO) is reported. Anorexia and dehydration preceded signs of encephalopathy after a cumulative dose of 18 g (11 g/m2) of MISO in five weekly doses. Serum MISO levels four hours after weekly administrations were markedly elevated. Postmortem examination revealed focal cortical neuronal necrosis and hemorrhage with focal demyelination. The possible relationship of dehydration or altered drug metabolism to the development of MISO central nervous system toxicity is noted.

AB - A case of fatal encephalopathy following administration of misonidazole (MISO) is reported. Anorexia and dehydration preceded signs of encephalopathy after a cumulative dose of 18 g (11 g/m2) of MISO in five weekly doses. Serum MISO levels four hours after weekly administrations were markedly elevated. Postmortem examination revealed focal cortical neuronal necrosis and hemorrhage with focal demyelination. The possible relationship of dehydration or altered drug metabolism to the development of MISO central nervous system toxicity is noted.

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Fatal misonidazole‐induced encephalopathy. An RTOG case report

Abstract

ASJC Scopus subject areas

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