Feasibility of allogeneic hematopoietic stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma

Mehdi Hamadani, Farrukh T. Awan, Patrick Elder, Thomas S. Lin, Pierluigi Porcu, Don M. Benson, Kristie A. Blum, Steven S. Devine

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of FL patients. Studies reporting outcomes of transformed FL patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are scant. Eight FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent HSCT at our institution. The median age was 56 years (range 44-63 years). Median follow-up is 60 months. Progression free survival and overall survival at 4-years for patients undergoing allogeneic HSCT is 56% and 66%, respectively. Four patients developed grade II-IV acute GVHD, whereas four patients had extensive chronic GVHD. Day 100 and overall non-relapse mortality rate was 12.5% and 25%, respectively. Allogeneic HSCT appears feasible in patients with transformed FL and is associated with acceptable treatment-related mortality and low relapse rates.

Original languageEnglish (US)
Pages (from-to)1893-1898
Number of pages6
JournalLeukemia and Lymphoma
Volume49
Issue number10
DOIs
StatePublished - Nov 5 2008
Externally publishedYes

Keywords

  • Diffuse large B-cell lymphoma
  • GVHD
  • Transformed follicular lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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