Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder

Matthew W. Mosconi, Suman Mohanty, Rachel K. Greene, Edwin H. Cook, David E. Vaillancourt, John A. Sweeney

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Sensorimotor abnormalities arecommonin autism spectrum disorder (ASD) andamongthe earliest manifestations of the disorder. They have been studied far less than the social-communication and cognitive deficits that define ASD, but a mechanistic understanding of sensorimotor abnormalities in ASD may provide key insights into the neural underpinnings of the disorder. In this human study, we examined rapid, precision grip force contractions to determine whether feedforward mechanisms supporting initial motor output before sensory feedback can be processed are disrupted in ASD. Sustained force contractions also were examined to determine whether reactive adjustments to ongoing motor behavior based on visual feedback are altered. Sustained force was studied across multiple force levels and visual gains to assess motor and visuomotor mechanisms, respectively. Primary force contractions of individuals with ASD showed greater peak rate of force increases and large transient overshoots. Individuals withASDalso showed increased sustained force variability that scaled with force level and was more severe when visual gain was highly amplified or highly degraded. When sustaining a constant force level, their reactive adjustments were more periodic than controls, and they showed increased reliance on slower feedback mechanisms. Feedforward and feedback mechanism alterations each were associated with more severe social-communication impairments in ASD. These findings implicate anterior cerebellar circuits involved in feedforward motor control and posterior cerebellar circuits involved in transforming visual feedback into precise motor adjustments in ASD.

Original languageEnglish (US)
Pages (from-to)2015-2025
Number of pages11
JournalJournal of Neuroscience
Volume35
Issue number5
DOIs
StatePublished - 2015

Fingerprint

Cerebellar Diseases
Social Adjustment
Sensory Feedback
Communication
Hand Strength
Autism Spectrum Disorder

Keywords

  • Autism spectrum disorder
  • Cerebellum
  • Precision grip
  • Sensorimotor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder. / Mosconi, Matthew W.; Mohanty, Suman; Greene, Rachel K.; Cook, Edwin H.; Vaillancourt, David E.; Sweeney, John A.

In: Journal of Neuroscience, Vol. 35, No. 5, 2015, p. 2015-2025.

Research output: Contribution to journalArticle

Mosconi, Matthew W. ; Mohanty, Suman ; Greene, Rachel K. ; Cook, Edwin H. ; Vaillancourt, David E. ; Sweeney, John A. / Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder. In: Journal of Neuroscience. 2015 ; Vol. 35, No. 5. pp. 2015-2025.
@article{efa631fa4ec74f7fadaf396c17ab0560,
title = "Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder",
abstract = "Sensorimotor abnormalities arecommonin autism spectrum disorder (ASD) andamongthe earliest manifestations of the disorder. They have been studied far less than the social-communication and cognitive deficits that define ASD, but a mechanistic understanding of sensorimotor abnormalities in ASD may provide key insights into the neural underpinnings of the disorder. In this human study, we examined rapid, precision grip force contractions to determine whether feedforward mechanisms supporting initial motor output before sensory feedback can be processed are disrupted in ASD. Sustained force contractions also were examined to determine whether reactive adjustments to ongoing motor behavior based on visual feedback are altered. Sustained force was studied across multiple force levels and visual gains to assess motor and visuomotor mechanisms, respectively. Primary force contractions of individuals with ASD showed greater peak rate of force increases and large transient overshoots. Individuals withASDalso showed increased sustained force variability that scaled with force level and was more severe when visual gain was highly amplified or highly degraded. When sustaining a constant force level, their reactive adjustments were more periodic than controls, and they showed increased reliance on slower feedback mechanisms. Feedforward and feedback mechanism alterations each were associated with more severe social-communication impairments in ASD. These findings implicate anterior cerebellar circuits involved in feedforward motor control and posterior cerebellar circuits involved in transforming visual feedback into precise motor adjustments in ASD.",
keywords = "Autism spectrum disorder, Cerebellum, Precision grip, Sensorimotor",
author = "Mosconi, {Matthew W.} and Suman Mohanty and Greene, {Rachel K.} and Cook, {Edwin H.} and Vaillancourt, {David E.} and Sweeney, {John A.}",
year = "2015",
doi = "10.1523/JNEUROSCI.2731-14.2015",
language = "English (US)",
volume = "35",
pages = "2015--2025",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "5",

}

TY - JOUR

T1 - Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder

AU - Mosconi, Matthew W.

AU - Mohanty, Suman

AU - Greene, Rachel K.

AU - Cook, Edwin H.

AU - Vaillancourt, David E.

AU - Sweeney, John A.

PY - 2015

Y1 - 2015

N2 - Sensorimotor abnormalities arecommonin autism spectrum disorder (ASD) andamongthe earliest manifestations of the disorder. They have been studied far less than the social-communication and cognitive deficits that define ASD, but a mechanistic understanding of sensorimotor abnormalities in ASD may provide key insights into the neural underpinnings of the disorder. In this human study, we examined rapid, precision grip force contractions to determine whether feedforward mechanisms supporting initial motor output before sensory feedback can be processed are disrupted in ASD. Sustained force contractions also were examined to determine whether reactive adjustments to ongoing motor behavior based on visual feedback are altered. Sustained force was studied across multiple force levels and visual gains to assess motor and visuomotor mechanisms, respectively. Primary force contractions of individuals with ASD showed greater peak rate of force increases and large transient overshoots. Individuals withASDalso showed increased sustained force variability that scaled with force level and was more severe when visual gain was highly amplified or highly degraded. When sustaining a constant force level, their reactive adjustments were more periodic than controls, and they showed increased reliance on slower feedback mechanisms. Feedforward and feedback mechanism alterations each were associated with more severe social-communication impairments in ASD. These findings implicate anterior cerebellar circuits involved in feedforward motor control and posterior cerebellar circuits involved in transforming visual feedback into precise motor adjustments in ASD.

AB - Sensorimotor abnormalities arecommonin autism spectrum disorder (ASD) andamongthe earliest manifestations of the disorder. They have been studied far less than the social-communication and cognitive deficits that define ASD, but a mechanistic understanding of sensorimotor abnormalities in ASD may provide key insights into the neural underpinnings of the disorder. In this human study, we examined rapid, precision grip force contractions to determine whether feedforward mechanisms supporting initial motor output before sensory feedback can be processed are disrupted in ASD. Sustained force contractions also were examined to determine whether reactive adjustments to ongoing motor behavior based on visual feedback are altered. Sustained force was studied across multiple force levels and visual gains to assess motor and visuomotor mechanisms, respectively. Primary force contractions of individuals with ASD showed greater peak rate of force increases and large transient overshoots. Individuals withASDalso showed increased sustained force variability that scaled with force level and was more severe when visual gain was highly amplified or highly degraded. When sustaining a constant force level, their reactive adjustments were more periodic than controls, and they showed increased reliance on slower feedback mechanisms. Feedforward and feedback mechanism alterations each were associated with more severe social-communication impairments in ASD. These findings implicate anterior cerebellar circuits involved in feedforward motor control and posterior cerebellar circuits involved in transforming visual feedback into precise motor adjustments in ASD.

KW - Autism spectrum disorder

KW - Cerebellum

KW - Precision grip

KW - Sensorimotor

UR - http://www.scopus.com/inward/record.url?scp=84922364361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922364361&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.2731-14.2015

DO - 10.1523/JNEUROSCI.2731-14.2015

M3 - Article

VL - 35

SP - 2015

EP - 2025

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 5

ER -