Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading

Research output: Contribution to journalArticle

305 Citations (Scopus)

Abstract

Fibroblast-collagen-matrix contraction provides a unique way to study reciprocal geometric and mechanical interactions between fibroblasts and extracellular matrix. Such interactions are difficult to appreciate or examine in routine cell culture because the culture surface is usually fixed in place. Forces exerted on collagen fibrils by cells cause isometric tension to develop in the cells if the collagen resists deformation; by contrast, the cells remain mechanically unloaded in the absence of matrix resistance. Recent evidence suggests that the state of cellular mechanical loading determines the mechanism that cells use to regulate contraction. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalTrends in Cell Biology
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2000

Fingerprint

Intercellular Signaling Peptides and Proteins
Collagen
Fibroblasts
Extracellular Matrix
Cell Culture Techniques

ASJC Scopus subject areas

  • Cell Biology

Cite this

Fibroblast-collagen-matrix contraction : growth-factor signalling and mechanical loading. / Grinnell, F.

In: Trends in Cell Biology, Vol. 10, No. 9, 01.09.2000, p. 362-365.

Research output: Contribution to journalArticle

@article{c077d8e988f8457fb78eacd71f773f05,
title = "Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading",
abstract = "Fibroblast-collagen-matrix contraction provides a unique way to study reciprocal geometric and mechanical interactions between fibroblasts and extracellular matrix. Such interactions are difficult to appreciate or examine in routine cell culture because the culture surface is usually fixed in place. Forces exerted on collagen fibrils by cells cause isometric tension to develop in the cells if the collagen resists deformation; by contrast, the cells remain mechanically unloaded in the absence of matrix resistance. Recent evidence suggests that the state of cellular mechanical loading determines the mechanism that cells use to regulate contraction. Copyright (C) 2000 Elsevier Science Ltd.",
author = "F. Grinnell",
year = "2000",
month = "9",
day = "1",
doi = "10.1016/S0962-8924(00)01802-X",
language = "English (US)",
volume = "10",
pages = "362--365",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "9",

}

TY - JOUR

T1 - Fibroblast-collagen-matrix contraction

T2 - growth-factor signalling and mechanical loading

AU - Grinnell, F.

PY - 2000/9/1

Y1 - 2000/9/1

N2 - Fibroblast-collagen-matrix contraction provides a unique way to study reciprocal geometric and mechanical interactions between fibroblasts and extracellular matrix. Such interactions are difficult to appreciate or examine in routine cell culture because the culture surface is usually fixed in place. Forces exerted on collagen fibrils by cells cause isometric tension to develop in the cells if the collagen resists deformation; by contrast, the cells remain mechanically unloaded in the absence of matrix resistance. Recent evidence suggests that the state of cellular mechanical loading determines the mechanism that cells use to regulate contraction. Copyright (C) 2000 Elsevier Science Ltd.

AB - Fibroblast-collagen-matrix contraction provides a unique way to study reciprocal geometric and mechanical interactions between fibroblasts and extracellular matrix. Such interactions are difficult to appreciate or examine in routine cell culture because the culture surface is usually fixed in place. Forces exerted on collagen fibrils by cells cause isometric tension to develop in the cells if the collagen resists deformation; by contrast, the cells remain mechanically unloaded in the absence of matrix resistance. Recent evidence suggests that the state of cellular mechanical loading determines the mechanism that cells use to regulate contraction. Copyright (C) 2000 Elsevier Science Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0034285081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034285081&partnerID=8YFLogxK

U2 - 10.1016/S0962-8924(00)01802-X

DO - 10.1016/S0962-8924(00)01802-X

M3 - Article

C2 - 10932093

AN - SCOPUS:0034285081

VL - 10

SP - 362

EP - 365

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 9

ER -