TY - JOUR
T1 - Fibroblast-collagen-matrix contraction
T2 - growth-factor signalling and mechanical loading
AU - Grinnell, F.
N1 - Funding Information:
My research is supported by a grant from the NIH (GM31321). Thanks to William Snell, Michael White and David Lee for their helpful comments and suggestions about the manuscript.
PY - 2000/9/1
Y1 - 2000/9/1
N2 - Fibroblast-collagen-matrix contraction provides a unique way to study reciprocal geometric and mechanical interactions between fibroblasts and extracellular matrix. Such interactions are difficult to appreciate or examine in routine cell culture because the culture surface is usually fixed in place. Forces exerted on collagen fibrils by cells cause isometric tension to develop in the cells if the collagen resists deformation; by contrast, the cells remain mechanically unloaded in the absence of matrix resistance. Recent evidence suggests that the state of cellular mechanical loading determines the mechanism that cells use to regulate contraction. Copyright (C) 2000 Elsevier Science Ltd.
AB - Fibroblast-collagen-matrix contraction provides a unique way to study reciprocal geometric and mechanical interactions between fibroblasts and extracellular matrix. Such interactions are difficult to appreciate or examine in routine cell culture because the culture surface is usually fixed in place. Forces exerted on collagen fibrils by cells cause isometric tension to develop in the cells if the collagen resists deformation; by contrast, the cells remain mechanically unloaded in the absence of matrix resistance. Recent evidence suggests that the state of cellular mechanical loading determines the mechanism that cells use to regulate contraction. Copyright (C) 2000 Elsevier Science Ltd.
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U2 - 10.1016/S0962-8924(00)01802-X
DO - 10.1016/S0962-8924(00)01802-X
M3 - Article
C2 - 10932093
AN - SCOPUS:0034285081
SN - 0962-8924
VL - 10
SP - 362
EP - 365
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 9
ER -