Fibroblast quiescence and the disruption of ERK signaling in mechanically unloaded collagen matrices

Hans Rosenfeldt, Frederick Grinnell

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Fibroblasts in mechanically unloaded collagen matrices had low levels of DNA synthesis compared with cells in mechanically loaded matrices. Under the former conditions, the cellular ERK signaling pathway appeared to be disrupted. Also, pharmacologic inhibition of ERK signaling blocked DNA synthesis by fibroblasts in mechanically loaded matrices. These results were consistent with the idea that mechanoregulation of fibroblast DNA synthesis in collagen matrices occurs at the level of the ERK signaling pathway.

Original languageEnglish (US)
Pages (from-to)3088-3092
Number of pages5
JournalJournal of Biological Chemistry
Volume275
Issue number5
DOIs
StatePublished - Feb 4 2000

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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