Flotillin and epidermal surface antigen define a new family of caveolae- associated integral membrane proteins

Perry E. Bickel, Philipp E. Scherer, Jan E. Schnitzer, Phil Oh, Michael P. Lisanti, Harvey F. Lodish

Research output: Contribution to journalArticle

474 Scopus citations

Abstract

Caveolae are plasmalemmal microdomains that are involved in vesicular trafficking and signal transduction. We have sought to identify novel integral membrane proteins of caveolae. Here we describe the identification and molecular cloning of flotillin. By several independent methods, flotillin behaves as a resident integral membrane protein component of caveolae. Furthermore, we have identified epidermal surface antigen both as a flotillin homologue and as a resident caveolar protein. Significantly, flotillin is a marker for the Triton-insoluble, buoyant membrane fraction in brain, where to date mRNA species for known caveolin gene family members have not been detected.

Original languageEnglish (US)
Pages (from-to)13793-13802
Number of pages10
JournalJournal of Biological Chemistry
Volume272
Issue number21
DOIs
StatePublished - May 23 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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