FMRI of working memory in patients with mild cognitive impairment and probable Alzheimer's disease

F. Zerrin Yetkin, Roger N. Rosenberg, Myron F. Weiner, Phillip D. Purdy, C. Munro Cullum

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

The goals of this study were to evaluate brain activation in patients with probable Alzheimer's disease (AD), mild cognitive impairment (MCI), and controls while performing a working memory (WM) task. Eleven AD patients, ten MCI subjects, and nine controls underwent functional magnetic resonance imaging (fMRI) while performing a visual WM task. Statistical parametric maps of brain activation were obtained in each group, and group activation difference maps were generated. Ability to perform the task did not differ among the groups. Activation was observed in the parahippocampal region, superior-middle-inferior frontal gyri, parietal region, anterior-posterior cingulate, fusiform gyrus, and basal ganglia. MCI and AD groups showed more activation than the controls in the right superior frontal gyrus, bilateral middle temporal, middle frontal, anterior cingulate, and fusiform gyri. Activation in the right parahippocampal gyrus, left inferior frontal gyrus, bilateral cingulate and lingual gyri, right lentiform nucleus, right fusiform gyrus, and left supramarginal gyrus in the AD group was less than in the MCI group. The WM task evoked activation in widely distributed regions, consistent with previous fMRI studies. AD and MCI patients showed an increased extent of activation and recruitment of additional areas.

Original languageEnglish (US)
Pages (from-to)193-206
Number of pages14
JournalEuropean Radiology
Volume16
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Short-Term Memory
Gyrus Cinguli
Alzheimer Disease
Temporal Lobe
Prefrontal Cortex
Parietal Lobe
Magnetic Resonance Imaging
Corpus Striatum
Occipital Lobe
Parahippocampal Gyrus
Aptitude
Brain
Basal Ganglia
Cognitive Dysfunction

Keywords

  • Alzheimer
  • Brain
  • Functional MR imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

FMRI of working memory in patients with mild cognitive impairment and probable Alzheimer's disease. / Yetkin, F. Zerrin; Rosenberg, Roger N.; Weiner, Myron F.; Purdy, Phillip D.; Cullum, C. Munro.

In: European Radiology, Vol. 16, No. 1, 01.2006, p. 193-206.

Research output: Contribution to journalArticle

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