Folate-encoded and Fe3O4-loaded polymeric micelles for dual targeting of cancer cells

Xiaoqiang Yang, Yinghua Chen, Renxu Yuan, Guihua Chen, Elvin Blanco, Jinming Gao, Xintao Shuai

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Diblock copolymers of poly(ethylene glycol) (PEG) and poly(ε-caprolactone) (PCL) bearing a tumor-targeting ligand, folate, were self-assembled into micelles. Superparamagnetic iron oxide (SPIO) nanoparticles and an anticancer drug doxorubicin (DOX) were coencapsulated within the micelles less than 100 nm in diameters. These SPIO-DOX-loaded micelles were superparamagnetic at room temperature, but turned ferrimagnetic at 10 K, consistent with magnetic properties of primary SPIO nanoparticles. Cell culture experiments demonstrated the potential of these polymeric micelles as an effective dual targeting nanoplatform for the delivery of anticancer drugs. Folate attachment to micelles resulted in the recognition of the micelles by tumor cells over-expressing folate receptors, leading to facilitation in cellular uptake of micelles, and the transport efficiency of the SPIO-loaded and folate-functionalized micelles into the tumor cells can be further enhanced by applying an external magnetic field to the cells.

Original languageEnglish (US)
Pages (from-to)3477-3485
Number of pages9
JournalPolymer
Volume49
Issue number16
DOIs
StatePublished - Jul 28 2008

Fingerprint

Micelles
Folic Acid
Cells
Iron oxides
Tumors
Doxorubicin
Polyethylene glycols
Bearings (structural)
Nanoparticles
Cell culture
Pharmaceutical Preparations
Block copolymers
Magnetic properties
Ligands
Magnetic fields
ferric oxide

Keywords

  • Block copolymers
  • Drug delivery
  • Micelles

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

Cite this

Folate-encoded and Fe3O4-loaded polymeric micelles for dual targeting of cancer cells. / Yang, Xiaoqiang; Chen, Yinghua; Yuan, Renxu; Chen, Guihua; Blanco, Elvin; Gao, Jinming; Shuai, Xintao.

In: Polymer, Vol. 49, No. 16, 28.07.2008, p. 3477-3485.

Research output: Contribution to journalArticle

Yang, X, Chen, Y, Yuan, R, Chen, G, Blanco, E, Gao, J & Shuai, X 2008, 'Folate-encoded and Fe3O4-loaded polymeric micelles for dual targeting of cancer cells', Polymer, vol. 49, no. 16, pp. 3477-3485. https://doi.org/10.1016/j.polymer.2008.06.005
Yang, Xiaoqiang ; Chen, Yinghua ; Yuan, Renxu ; Chen, Guihua ; Blanco, Elvin ; Gao, Jinming ; Shuai, Xintao. / Folate-encoded and Fe3O4-loaded polymeric micelles for dual targeting of cancer cells. In: Polymer. 2008 ; Vol. 49, No. 16. pp. 3477-3485.
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AU - Yuan, Renxu

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AU - Blanco, Elvin

AU - Gao, Jinming

AU - Shuai, Xintao

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AB - Diblock copolymers of poly(ethylene glycol) (PEG) and poly(ε-caprolactone) (PCL) bearing a tumor-targeting ligand, folate, were self-assembled into micelles. Superparamagnetic iron oxide (SPIO) nanoparticles and an anticancer drug doxorubicin (DOX) were coencapsulated within the micelles less than 100 nm in diameters. These SPIO-DOX-loaded micelles were superparamagnetic at room temperature, but turned ferrimagnetic at 10 K, consistent with magnetic properties of primary SPIO nanoparticles. Cell culture experiments demonstrated the potential of these polymeric micelles as an effective dual targeting nanoplatform for the delivery of anticancer drugs. Folate attachment to micelles resulted in the recognition of the micelles by tumor cells over-expressing folate receptors, leading to facilitation in cellular uptake of micelles, and the transport efficiency of the SPIO-loaded and folate-functionalized micelles into the tumor cells can be further enhanced by applying an external magnetic field to the cells.

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