Folate receptor imaging with 125I labeled folic acid with a whole body small animal imaging device built with plastic scintillating optical fibers

P. V. Kulkarni, P. P. Antich, A. Constantinescu, J. Prior, T. Nguyen, J. Fernando, J. A. Anderson, S. D. Weitman, B. A. Kamen, R. W. Parkey, R. C. Chaney, E. J. Fenyves

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Abstract

A small animal whole body imaging cylindrical device was built with plastic scintillating fibers and position sensitive photomultipliers (Hamamatsu) and digitized using flash ADCs. A co-axial brass mesh collimator (septum thickness 1 mm) was used in combination with an electronic collimation scheme to enhance spatial resolution. Imaging studies with 125I labeled folic acid were performed in mice bearing folate receptor +ve (IGROV) tumor and receptor -ve (Meth-A) tumor. In-situ imaging of animals sacrificed at 15-30 min post injection of the tracer showed the localization of the tumor in animals with the folate receptor +ve tumors. Our initial studies demonstrate the utility of a device built with plastic scintillating fibers in small animal imaging studies with low energy photons (25-35 keV).

Original languageEnglish (US)
Pages (from-to)800-803
Number of pages4
JournalNuclear Inst. and Methods in Physics Research, B
Volume99
Issue number1-4
DOIs
Publication statusPublished - May 5 1995

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ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics

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