Food Allergy Immunotherapy with Adjuvants

Rory E. Nicolaides; Christopher P. Parrish; J. Andrew Bird

doi:10.1016/j.iac.2019.09.004

Food Allergy Immunotherapy with Adjuvants

Rory E. Nicolaides, Christopher P. Parrish, J. Andrew Bird

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Treatment of immunoglobulin E–mediated food allergy has traditionally been limited to allergen avoidance and emergency treatment after accidental ingestion. In recent years, significant progress has been made with oral, sublingual, and epicutaneous immunotherapy in the treatment of food allergy; however, these emerging treatment options have important limitations in efficacy, durability of effect, and safety. These limitations have already spurred interest in the development of adjuvant therapies to increase efficacy, produce more durable immunologic changes, and/or reduce treatment-related adverse reactions.

Original language	English (US)
Pages (from-to)	149-173
Number of pages	25
Journal	Immunology and Allergy Clinics of North America
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/j.iac.2019.09.004
State	Published - Feb 2020

Keywords

Adjuvant therapy
EPIT
Food allergy
Modified allergens
OIT
SLIT

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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abstract = "Treatment of immunoglobulin E–mediated food allergy has traditionally been limited to allergen avoidance and emergency treatment after accidental ingestion. In recent years, significant progress has been made with oral, sublingual, and epicutaneous immunotherapy in the treatment of food allergy; however, these emerging treatment options have important limitations in efficacy, durability of effect, and safety. These limitations have already spurred interest in the development of adjuvant therapies to increase efficacy, produce more durable immunologic changes, and/or reduce treatment-related adverse reactions.",

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