Frameless, real-time, surface imaging-guided radiosurgery: Update on clinical outcomes for brain metastases

Nhat Long L. Pham, Pranav V. Reddy, James D. Murphy, Parag Sanghvi, Jona A. Hattangadi-Gluth, Grace Gwe Ya Kim, Laura Cervino, Todd Pawlicki, Kevin T. Murphy

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Frameless stereotactic radiosurgery (SRS) for intracranial brain metastases can provide more comfortable treatment setup than rigid frame-based immobilization with equivalent accuracy. The aim of this study is to report the UCSD SRS experience and update the clinical outcomes using a novel real-time, frameless, surface imaging-guided (SIG-RS) technique in the treatment of brain metastases. Data were retrospectively examined for 163 patients totaling 490 lesions and 45 post-operative cavities treated with SIG-RS in a median delivery of 1 fraction (range, 1-5 fraction) and to a median dose of 22 Gy (range, 12-30 Gy). Local control and overall survival were estimated by the Kaplan-Meier method. Median follow-up for all patients was 6.7 months (range, 0.5-45.1 months), with 119 of 163 (73%) deceased at the time of analysis. The 134 patients (82%) with follow-up imaging studies totaling 378 lesions and 39 post-operative cavities were evaluated for local control. The actuarial 6- and 12-month local control was 90% [95% confidence interval (CI), 84-94%] and 79% (95% CI, 71-86%), respectively. The actuarial 6- and 12-month overall survival was 80% (95% CI, 74-85%) and 56% (95% CI, 49-63%), respectively. There is no significant difference in local control between treatment to post-operative cavities or intact lesions. Consistent with our earlier report of 44 patients, SIG-RS for treatment of intracranial metastases can produce outcomes comparable to those with conventional frame-based and frameless SRS techniques while providing greater patient comfort with an open-faced mask and fast treatment time.

Original languageEnglish (US)
Pages (from-to)351-357
Number of pages7
JournalTranslational Cancer Research
Volume3
Issue number4
DOIs
StatePublished - Aug 1 2014

Fingerprint

Radiosurgery
Neoplasm Metastasis
Confidence Intervals
Brain
Stereotaxic Techniques
Therapeutics
Survival
Masks
Immobilization

Keywords

  • Frameless
  • Intracranial brain metastases
  • Radiosurgery
  • Surface imaging

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Pham, N. L. L., Reddy, P. V., Murphy, J. D., Sanghvi, P., Hattangadi-Gluth, J. A., Kim, G. G. Y., ... Murphy, K. T. (2014). Frameless, real-time, surface imaging-guided radiosurgery: Update on clinical outcomes for brain metastases. Translational Cancer Research, 3(4), 351-357. https://doi.org/10.3978/j.issn.2218-676X.2014.07.08

Frameless, real-time, surface imaging-guided radiosurgery : Update on clinical outcomes for brain metastases. / Pham, Nhat Long L.; Reddy, Pranav V.; Murphy, James D.; Sanghvi, Parag; Hattangadi-Gluth, Jona A.; Kim, Grace Gwe Ya; Cervino, Laura; Pawlicki, Todd; Murphy, Kevin T.

In: Translational Cancer Research, Vol. 3, No. 4, 01.08.2014, p. 351-357.

Research output: Contribution to journalReview article

Pham, NLL, Reddy, PV, Murphy, JD, Sanghvi, P, Hattangadi-Gluth, JA, Kim, GGY, Cervino, L, Pawlicki, T & Murphy, KT 2014, 'Frameless, real-time, surface imaging-guided radiosurgery: Update on clinical outcomes for brain metastases', Translational Cancer Research, vol. 3, no. 4, pp. 351-357. https://doi.org/10.3978/j.issn.2218-676X.2014.07.08
Pham, Nhat Long L. ; Reddy, Pranav V. ; Murphy, James D. ; Sanghvi, Parag ; Hattangadi-Gluth, Jona A. ; Kim, Grace Gwe Ya ; Cervino, Laura ; Pawlicki, Todd ; Murphy, Kevin T. / Frameless, real-time, surface imaging-guided radiosurgery : Update on clinical outcomes for brain metastases. In: Translational Cancer Research. 2014 ; Vol. 3, No. 4. pp. 351-357.
@article{cf4b4cfc5581496c855de50763667d99,
title = "Frameless, real-time, surface imaging-guided radiosurgery: Update on clinical outcomes for brain metastases",
abstract = "Frameless stereotactic radiosurgery (SRS) for intracranial brain metastases can provide more comfortable treatment setup than rigid frame-based immobilization with equivalent accuracy. The aim of this study is to report the UCSD SRS experience and update the clinical outcomes using a novel real-time, frameless, surface imaging-guided (SIG-RS) technique in the treatment of brain metastases. Data were retrospectively examined for 163 patients totaling 490 lesions and 45 post-operative cavities treated with SIG-RS in a median delivery of 1 fraction (range, 1-5 fraction) and to a median dose of 22 Gy (range, 12-30 Gy). Local control and overall survival were estimated by the Kaplan-Meier method. Median follow-up for all patients was 6.7 months (range, 0.5-45.1 months), with 119 of 163 (73{\%}) deceased at the time of analysis. The 134 patients (82{\%}) with follow-up imaging studies totaling 378 lesions and 39 post-operative cavities were evaluated for local control. The actuarial 6- and 12-month local control was 90{\%} [95{\%} confidence interval (CI), 84-94{\%}] and 79{\%} (95{\%} CI, 71-86{\%}), respectively. The actuarial 6- and 12-month overall survival was 80{\%} (95{\%} CI, 74-85{\%}) and 56{\%} (95{\%} CI, 49-63{\%}), respectively. There is no significant difference in local control between treatment to post-operative cavities or intact lesions. Consistent with our earlier report of 44 patients, SIG-RS for treatment of intracranial metastases can produce outcomes comparable to those with conventional frame-based and frameless SRS techniques while providing greater patient comfort with an open-faced mask and fast treatment time.",
keywords = "Frameless, Intracranial brain metastases, Radiosurgery, Surface imaging",
author = "Pham, {Nhat Long L.} and Reddy, {Pranav V.} and Murphy, {James D.} and Parag Sanghvi and Hattangadi-Gluth, {Jona A.} and Kim, {Grace Gwe Ya} and Laura Cervino and Todd Pawlicki and Murphy, {Kevin T.}",
year = "2014",
month = "8",
day = "1",
doi = "10.3978/j.issn.2218-676X.2014.07.08",
language = "English (US)",
volume = "3",
pages = "351--357",
journal = "Translational Cancer Research",
issn = "2218-676X",
publisher = "AME Publishing Company",
number = "4",

}

TY - JOUR

T1 - Frameless, real-time, surface imaging-guided radiosurgery

T2 - Update on clinical outcomes for brain metastases

AU - Pham, Nhat Long L.

AU - Reddy, Pranav V.

AU - Murphy, James D.

AU - Sanghvi, Parag

AU - Hattangadi-Gluth, Jona A.

AU - Kim, Grace Gwe Ya

AU - Cervino, Laura

AU - Pawlicki, Todd

AU - Murphy, Kevin T.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Frameless stereotactic radiosurgery (SRS) for intracranial brain metastases can provide more comfortable treatment setup than rigid frame-based immobilization with equivalent accuracy. The aim of this study is to report the UCSD SRS experience and update the clinical outcomes using a novel real-time, frameless, surface imaging-guided (SIG-RS) technique in the treatment of brain metastases. Data were retrospectively examined for 163 patients totaling 490 lesions and 45 post-operative cavities treated with SIG-RS in a median delivery of 1 fraction (range, 1-5 fraction) and to a median dose of 22 Gy (range, 12-30 Gy). Local control and overall survival were estimated by the Kaplan-Meier method. Median follow-up for all patients was 6.7 months (range, 0.5-45.1 months), with 119 of 163 (73%) deceased at the time of analysis. The 134 patients (82%) with follow-up imaging studies totaling 378 lesions and 39 post-operative cavities were evaluated for local control. The actuarial 6- and 12-month local control was 90% [95% confidence interval (CI), 84-94%] and 79% (95% CI, 71-86%), respectively. The actuarial 6- and 12-month overall survival was 80% (95% CI, 74-85%) and 56% (95% CI, 49-63%), respectively. There is no significant difference in local control between treatment to post-operative cavities or intact lesions. Consistent with our earlier report of 44 patients, SIG-RS for treatment of intracranial metastases can produce outcomes comparable to those with conventional frame-based and frameless SRS techniques while providing greater patient comfort with an open-faced mask and fast treatment time.

AB - Frameless stereotactic radiosurgery (SRS) for intracranial brain metastases can provide more comfortable treatment setup than rigid frame-based immobilization with equivalent accuracy. The aim of this study is to report the UCSD SRS experience and update the clinical outcomes using a novel real-time, frameless, surface imaging-guided (SIG-RS) technique in the treatment of brain metastases. Data were retrospectively examined for 163 patients totaling 490 lesions and 45 post-operative cavities treated with SIG-RS in a median delivery of 1 fraction (range, 1-5 fraction) and to a median dose of 22 Gy (range, 12-30 Gy). Local control and overall survival were estimated by the Kaplan-Meier method. Median follow-up for all patients was 6.7 months (range, 0.5-45.1 months), with 119 of 163 (73%) deceased at the time of analysis. The 134 patients (82%) with follow-up imaging studies totaling 378 lesions and 39 post-operative cavities were evaluated for local control. The actuarial 6- and 12-month local control was 90% [95% confidence interval (CI), 84-94%] and 79% (95% CI, 71-86%), respectively. The actuarial 6- and 12-month overall survival was 80% (95% CI, 74-85%) and 56% (95% CI, 49-63%), respectively. There is no significant difference in local control between treatment to post-operative cavities or intact lesions. Consistent with our earlier report of 44 patients, SIG-RS for treatment of intracranial metastases can produce outcomes comparable to those with conventional frame-based and frameless SRS techniques while providing greater patient comfort with an open-faced mask and fast treatment time.

KW - Frameless

KW - Intracranial brain metastases

KW - Radiosurgery

KW - Surface imaging

UR - http://www.scopus.com/inward/record.url?scp=84962756687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962756687&partnerID=8YFLogxK

U2 - 10.3978/j.issn.2218-676X.2014.07.08

DO - 10.3978/j.issn.2218-676X.2014.07.08

M3 - Review article

AN - SCOPUS:84962756687

VL - 3

SP - 351

EP - 357

JO - Translational Cancer Research

JF - Translational Cancer Research

SN - 2218-676X

IS - 4

ER -