Frequency domain tomography in small animals with the equation of radiative transfer

Kui Ren, Bryte Moa-Anderson, Guillaume Bal, Xuejun Gu, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

We have developed a model-based iterative image reconstruction scheme based on the equation of radiative transfer in the frequency domain for the applications in small animal optical tomographic imaging. To test the utility of such a code in small animal imaging we have furthermore developed a numerical phantom of a mouse. In simulation studies using this and other phantoms, we found that to make truly use of phase information in the reconstruction process modulation frequencies well above 100 MHz are necessary. Only at these higher frequencies the phase shifts introduced by the lesions of interest are large enough to be measured. For smaller frequencies no substantial improvements over steady-state systems are achieved in small geometries typical for small animal imaging.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsB. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca
Pages111-120
Number of pages10
Volume5693
DOIs
StatePublished - 2005
EventOptical Tomography and Spectroscopy of Tissue VI - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

Other

OtherOptical Tomography and Spectroscopy of Tissue VI
CountryUnited States
CitySan Jose, CA
Period1/23/051/26/05

Fingerprint

Radiative transfer
Tomography
Animals
Imaging techniques
Frequency modulation
Image reconstruction
Phase shift
Geometry

Keywords

  • Discrete ordinate
  • Equation of radiative transfer
  • Finite volume method
  • Inverse problems
  • Optical tomography
  • Small animal imaging

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Ren, K., Moa-Anderson, B., Bal, G., Gu, X., & Hielscher, A. H. (2005). Frequency domain tomography in small animals with the equation of radiative transfer. In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraca (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5693, pp. 111-120). [22] https://doi.org/10.1117/12.591113

Frequency domain tomography in small animals with the equation of radiative transfer. / Ren, Kui; Moa-Anderson, Bryte; Bal, Guillaume; Gu, Xuejun; Hielscher, Andreas H.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / B. Chance; R.R. Alfano; B.J. Tromberg; M. Tamura; E.M. Sevick-Muraca. Vol. 5693 2005. p. 111-120 22.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ren, K, Moa-Anderson, B, Bal, G, Gu, X & Hielscher, AH 2005, Frequency domain tomography in small animals with the equation of radiative transfer. in B Chance, RR Alfano, BJ Tromberg, M Tamura & EM Sevick-Muraca (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5693, 22, pp. 111-120, Optical Tomography and Spectroscopy of Tissue VI, San Jose, CA, United States, 1/23/05. https://doi.org/10.1117/12.591113
Ren K, Moa-Anderson B, Bal G, Gu X, Hielscher AH. Frequency domain tomography in small animals with the equation of radiative transfer. In Chance B, Alfano RR, Tromberg BJ, Tamura M, Sevick-Muraca EM, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 5693. 2005. p. 111-120. 22 https://doi.org/10.1117/12.591113
Ren, Kui ; Moa-Anderson, Bryte ; Bal, Guillaume ; Gu, Xuejun ; Hielscher, Andreas H. / Frequency domain tomography in small animals with the equation of radiative transfer. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / B. Chance ; R.R. Alfano ; B.J. Tromberg ; M. Tamura ; E.M. Sevick-Muraca. Vol. 5693 2005. pp. 111-120
@inproceedings{901db882ce994228b79ee279e02ec5c5,
title = "Frequency domain tomography in small animals with the equation of radiative transfer",
abstract = "We have developed a model-based iterative image reconstruction scheme based on the equation of radiative transfer in the frequency domain for the applications in small animal optical tomographic imaging. To test the utility of such a code in small animal imaging we have furthermore developed a numerical phantom of a mouse. In simulation studies using this and other phantoms, we found that to make truly use of phase information in the reconstruction process modulation frequencies well above 100 MHz are necessary. Only at these higher frequencies the phase shifts introduced by the lesions of interest are large enough to be measured. For smaller frequencies no substantial improvements over steady-state systems are achieved in small geometries typical for small animal imaging.",
keywords = "Discrete ordinate, Equation of radiative transfer, Finite volume method, Inverse problems, Optical tomography, Small animal imaging",
author = "Kui Ren and Bryte Moa-Anderson and Guillaume Bal and Xuejun Gu and Hielscher, {Andreas H.}",
year = "2005",
doi = "10.1117/12.591113",
language = "English (US)",
volume = "5693",
pages = "111--120",
editor = "B. Chance and R.R. Alfano and B.J. Tromberg and M. Tamura and E.M. Sevick-Muraca",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Frequency domain tomography in small animals with the equation of radiative transfer

AU - Ren, Kui

AU - Moa-Anderson, Bryte

AU - Bal, Guillaume

AU - Gu, Xuejun

AU - Hielscher, Andreas H.

PY - 2005

Y1 - 2005

N2 - We have developed a model-based iterative image reconstruction scheme based on the equation of radiative transfer in the frequency domain for the applications in small animal optical tomographic imaging. To test the utility of such a code in small animal imaging we have furthermore developed a numerical phantom of a mouse. In simulation studies using this and other phantoms, we found that to make truly use of phase information in the reconstruction process modulation frequencies well above 100 MHz are necessary. Only at these higher frequencies the phase shifts introduced by the lesions of interest are large enough to be measured. For smaller frequencies no substantial improvements over steady-state systems are achieved in small geometries typical for small animal imaging.

AB - We have developed a model-based iterative image reconstruction scheme based on the equation of radiative transfer in the frequency domain for the applications in small animal optical tomographic imaging. To test the utility of such a code in small animal imaging we have furthermore developed a numerical phantom of a mouse. In simulation studies using this and other phantoms, we found that to make truly use of phase information in the reconstruction process modulation frequencies well above 100 MHz are necessary. Only at these higher frequencies the phase shifts introduced by the lesions of interest are large enough to be measured. For smaller frequencies no substantial improvements over steady-state systems are achieved in small geometries typical for small animal imaging.

KW - Discrete ordinate

KW - Equation of radiative transfer

KW - Finite volume method

KW - Inverse problems

KW - Optical tomography

KW - Small animal imaging

UR - http://www.scopus.com/inward/record.url?scp=23244452937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23244452937&partnerID=8YFLogxK

U2 - 10.1117/12.591113

DO - 10.1117/12.591113

M3 - Conference contribution

VL - 5693

SP - 111

EP - 120

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

A2 - Chance, B.

A2 - Alfano, R.R.

A2 - Tromberg, B.J.

A2 - Tamura, M.

A2 - Sevick-Muraca, E.M.

ER -