From medications to surgery: Advances in the treatment of motor complications in Parkinson's disease

Kanae Jennifer Nagao, Neepa J. Patel

Research output: Contribution to journalReview article

Abstract

Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fuctuations and dyskinesia.

Original languageEnglish (US)
Article number212592
JournalDrugs in Context
Volume8
DOIs
StatePublished - 2019

Keywords

  • Deep brain stimulation
  • Levodopa
  • Parkinson's disease
  • Therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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