From stem cells to lymphocytes: Biology and transplantation

Hector L. Aguila, Koichi Akashi, Jos Domen, Kimberly L. Gandy, Eric Lagasse, Reina E. Mebius, Sean J. Morrison, Judy Shizuru, Samuel Strober, Nobuko Uchida, Douglas E. Wright, Irving L. Weissman

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

Original languageEnglish (US)
Pages (from-to)13-39
Number of pages27
JournalImmunological Reviews
Volume157
DOIs
StatePublished - 1997

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Hematopoietic System
Hematopoietic Stem Cells
Stem Cells
Transplantation
Lymphocytes
T-Lymphocytes
Histocompatibility
Hematopoietic Stem Cell Transplantation
Graft Rejection
Thymus Gland
Homeostasis
Lymph Nodes
Bone Marrow

ASJC Scopus subject areas

  • Immunology

Cite this

Aguila, H. L., Akashi, K., Domen, J., Gandy, K. L., Lagasse, E., Mebius, R. E., ... Weissman, I. L. (1997). From stem cells to lymphocytes: Biology and transplantation. Immunological Reviews, 157, 13-39. https://doi.org/10.1111/j.1600-065X.1997.tb00971.x

From stem cells to lymphocytes : Biology and transplantation. / Aguila, Hector L.; Akashi, Koichi; Domen, Jos; Gandy, Kimberly L.; Lagasse, Eric; Mebius, Reina E.; Morrison, Sean J.; Shizuru, Judy; Strober, Samuel; Uchida, Nobuko; Wright, Douglas E.; Weissman, Irving L.

In: Immunological Reviews, Vol. 157, 1997, p. 13-39.

Research output: Contribution to journalArticle

Aguila, HL, Akashi, K, Domen, J, Gandy, KL, Lagasse, E, Mebius, RE, Morrison, SJ, Shizuru, J, Strober, S, Uchida, N, Wright, DE & Weissman, IL 1997, 'From stem cells to lymphocytes: Biology and transplantation', Immunological Reviews, vol. 157, pp. 13-39. https://doi.org/10.1111/j.1600-065X.1997.tb00971.x
Aguila HL, Akashi K, Domen J, Gandy KL, Lagasse E, Mebius RE et al. From stem cells to lymphocytes: Biology and transplantation. Immunological Reviews. 1997;157:13-39. https://doi.org/10.1111/j.1600-065X.1997.tb00971.x
Aguila, Hector L. ; Akashi, Koichi ; Domen, Jos ; Gandy, Kimberly L. ; Lagasse, Eric ; Mebius, Reina E. ; Morrison, Sean J. ; Shizuru, Judy ; Strober, Samuel ; Uchida, Nobuko ; Wright, Douglas E. ; Weissman, Irving L. / From stem cells to lymphocytes : Biology and transplantation. In: Immunological Reviews. 1997 ; Vol. 157. pp. 13-39.
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