From top to bottom: Midkine and pleiotrophin as emerging players in immune regulation

Noah Sorrelle, Adrian T.A. Dominguez, Rolf A. Brekken

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in a wide array of inflammatory diseases and cancer. In this minireview, we will discuss the emerging appreciation of the functions of the MK/PTN family in the immune system, which include promoting lymphocyte survival, sculpting myeloid cell phenotype, driving immune cell chemotaxis, and maintaining hematopoiesis.

Original languageEnglish (US)
Pages (from-to)277-286
Number of pages10
JournalJournal of Leukocyte Biology
Volume102
Issue number2
DOIs
StatePublished - Aug 1 2017

Keywords

  • Cytokines
  • Hematopoiesis
  • Lymphoid cells
  • Myeloid cells

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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