TY - JOUR
T1 - From top to bottom
T2 - Midkine and pleiotrophin as emerging players in immune regulation
AU - Sorrelle, Noah
AU - Dominguez, Adrian T.A.
AU - Brekken, Rolf A.
N1 - Funding Information:
This work was supported in part by grants from the U.S. National Institutes of Health (1F31 CA19603301 to N.S.) and the Effie Marie Cain Scholarship in Angiogenesis Research and the Mary Kay Foundation (to R.A.B.).
Publisher Copyright:
© Society for Leukocyte Biology.
PY - 2017/8
Y1 - 2017/8
N2 - Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in a wide array of inflammatory diseases and cancer. In this minireview, we will discuss the emerging appreciation of the functions of the MK/PTN family in the immune system, which include promoting lymphocyte survival, sculpting myeloid cell phenotype, driving immune cell chemotaxis, and maintaining hematopoiesis.
AB - Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in a wide array of inflammatory diseases and cancer. In this minireview, we will discuss the emerging appreciation of the functions of the MK/PTN family in the immune system, which include promoting lymphocyte survival, sculpting myeloid cell phenotype, driving immune cell chemotaxis, and maintaining hematopoiesis.
KW - Cytokines
KW - Hematopoiesis
KW - Lymphoid cells
KW - Myeloid cells
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U2 - 10.1189/jlb.3MR1116-475R
DO - 10.1189/jlb.3MR1116-475R
M3 - Review article
C2 - 28356350
AN - SCOPUS:85026776989
SN - 0741-5400
VL - 102
SP - 277
EP - 286
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 2
ER -