Functional treatments in multiple sclerosis

Ardith M. Courtney, Wanda Castro-Borrero, Scott L. Davis, Teresa C. Frohman, Elliot Frohman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose of Review: This review focuses on recent advances in the understanding and management of symptoms and dysfunctions associated with multiple sclerosis (MS). Recent Findings: A broad spectrum of dysfunctions associated with MS are under investigation. Research published in the past year and a half addresses gait dysfunction, exercise training, fatigue, bowel/bladder and sexual dysfunction, and sleep disruption. Functional electrical stimulation and strength training have been validated for improvement in gait and motor function. Exercise training has been shown to benefit mood and quality of life scores and to reduce circulating inflammatory cytokine levels. Fatigue remains a challenging problem with incremental improvements in understanding of underlying causes and effective drug therapies offered by recent work. Treatment of bowel, bladder and sexual dysfunction utilizing a variety of modalities has been investigated with some progress. Summary: In the absence of treatments to reverse neurologic injury due to MS, effective symptom management and functional improvement remain essential to mitigate disability and maintain quality of life. Basic research, as well as controlled clinical trials, in this realm offers promising insights and solutions.

Original languageEnglish (US)
Pages (from-to)250-254
Number of pages5
JournalCurrent Opinion in Neurology
Volume24
Issue number3
DOIs
StatePublished - Jun 2011

Fingerprint

Multiple Sclerosis
Gait
Fatigue
Urinary Bladder
Quality of Life
Exercise
Nervous System Trauma
Resistance Training
Controlled Clinical Trials
Research
Electric Stimulation
Sleep
Therapeutics
Cytokines
Drug Therapy

Keywords

  • fatigue
  • gait
  • multiple sclerosis
  • sexual dysfunction
  • sleep
  • symptom management

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Courtney, A. M., Castro-Borrero, W., Davis, S. L., Frohman, T. C., & Frohman, E. (2011). Functional treatments in multiple sclerosis. Current Opinion in Neurology, 24(3), 250-254. https://doi.org/10.1097/WCO.0b013e328346055a

Functional treatments in multiple sclerosis. / Courtney, Ardith M.; Castro-Borrero, Wanda; Davis, Scott L.; Frohman, Teresa C.; Frohman, Elliot.

In: Current Opinion in Neurology, Vol. 24, No. 3, 06.2011, p. 250-254.

Research output: Contribution to journalArticle

Courtney, AM, Castro-Borrero, W, Davis, SL, Frohman, TC & Frohman, E 2011, 'Functional treatments in multiple sclerosis', Current Opinion in Neurology, vol. 24, no. 3, pp. 250-254. https://doi.org/10.1097/WCO.0b013e328346055a
Courtney, Ardith M. ; Castro-Borrero, Wanda ; Davis, Scott L. ; Frohman, Teresa C. ; Frohman, Elliot. / Functional treatments in multiple sclerosis. In: Current Opinion in Neurology. 2011 ; Vol. 24, No. 3. pp. 250-254.
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