Furosemide in the intraoperative reduction of intracranial pressure in the patient with subarachnoid hemorrhage

D. Samson, C. W. Beyer

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Abstract

The effect of furosemide in the intraoperative reduction of intracranial pressure was measured in 25 patients undergoing the operative repair of a ruptured intracranial aneurysm. Seven patients with similar intracranial lesions served as controls. A single bolus of 80 mg of furosemide was administered intravenously after the induction of anesthesia, and sequential measurements were made of intracranial pressure, mean arterial pressure, and arterial blood gases. A mean decrease of intracranial pressure of 56% was measured in the furosemide-treated patients, whereas the control patients demonstrated a mean decline of subarachnoid pressures of 18%. These changes are significant at the P<0.005 confidence level, whereas changes in mean arterial pressure, mean arterial pCO2, and base line arterial pCO2 were statistically insignificant. This study suggests that intravenous furosemide is a quick, dependable, and effective mechanism for the intraoperative reduction of intracranial pressure in the postsubarachnoid hemorrhage aneurysm patient.

Original languageEnglish (US)
Pages (from-to)167-169
Number of pages3
JournalNeurosurgery
Volume10
Issue number2
StatePublished - Jan 1 1982

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ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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