Future Perspectives of Cardiovascular Biomarker Utilization in Cancer Survivors: A Scientific Statement From the American Heart Association

Vlad G. Zaha, Salim S. Hayek, Kevin M. Alexander, Theresa M. Beckie, W. Gregory Hundley, Lavanya Kondapalli, Bonnie Ky, Kasey J. Leger, Wouter C. Meijers, Javid J. Moslehi, Svati H. Shah

Research output: Contribution to journalArticlepeer-review

Abstract

Improving cancer survival represents the most significant effect of precision medicine and personalized molecular and immunologic therapeutics. Cardiovascular health becomes henceforth a key determinant for the direction of overall outcomes after cancer. Comprehensive tissue diagnostic studies undoubtedly have been and continue to be at the core of the fight against cancer. Will a systemic approach integrating circulating blood-derived biomarkers, multimodality imaging technologies, strategic panomics, and real-time streams of digitized physiological data overcome the elusive cardiovascular tissue diagnosis in cardio-oncology? How can such a systemic approach be personalized for application in day-to-day clinical work, with diverse patient populations, cancer diagnoses, and therapies? To address such questions, this scientific statement approaches a broad definition of the biomarker concept. It summarizes the current literature on the utilization of a multitude of established cardiovascular biomarkers at the intersection with cancer. It identifies limitations and gaps of knowledge in the application of biomarkers to stratify the cardiovascular risk before cancer treatment, monitor cardiovascular health during cancer therapy, and detect latent cardiovascular damage in cancer survivors. Last, it highlights areas in biomarker discovery, validation, and clinical application for concerted efforts from funding agencies, scientists, and clinicians at the cardio-oncology nexus.

Original languageEnglish (US)
Pages (from-to)E551-E563
JournalCirculation
Volume144
Issue number25
DOIs
StatePublished - Dec 21 2021

Keywords

  • AHA Scientific Statements
  • biomarkers
  • cancer survivors
  • cardiology
  • oncology
  • precision medicine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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