TY - JOUR
T1 - G protein-coupled receptors in stem cell maintenance and somatic reprogramming to pluripotent or cancer stem cells
AU - Choi, Hye Yeon
AU - Saha, Subbroto Kumar
AU - Kim, Kyeongseok
AU - Kim, Sangsu
AU - Yang, Gwang Mo
AU - Kim, Bong Woo
AU - Kim, Jin hoi
AU - Cho, Ssang Goo
N1 - Publisher Copyright:
© 2015 by the The Korean Society for Biochemistry and Molecular Biology.
PY - 2015
Y1 - 2015
N2 - G protein-coupled receptors (GPCRs) are a large class of transmembrane receptors categorized into five distinct families: rhodopsin, secretin, adhesion, glutamate, and frizzled. They bind and regulate 80% of all hormones and account for 20-50% of the pharmaceuticals currently on the market. Hundreds of GPCRs integrate and coordinate the functions of individual cells, mediating signaling between various organs. GPCRs are crucial players in tumor progression, adipogenesis, and inflammation. Several studies have also confirmed their central roles in embryonic development and stem cell maintenance. Recently, GPCRs have emerged as key players in the regulation of cell survival, proliferation, migration, and self-renewal in pluripotent (PSCs) and cancer stem cells (CSCs). Our study and other reports have revealed that the expression of many GPCRs is modulated during the generation of induced PSCs (iPSCs) or CSCs as well as during CSC sphere formation. These GPCRs may have crucial roles in the regulation of selfrenewal and other biological properties of iPSCs and CSCs. This review addresses the current understanding of the role of GPCRs in stem cell maintenance and somatic reprogramming to PSCs or CSCs.
AB - G protein-coupled receptors (GPCRs) are a large class of transmembrane receptors categorized into five distinct families: rhodopsin, secretin, adhesion, glutamate, and frizzled. They bind and regulate 80% of all hormones and account for 20-50% of the pharmaceuticals currently on the market. Hundreds of GPCRs integrate and coordinate the functions of individual cells, mediating signaling between various organs. GPCRs are crucial players in tumor progression, adipogenesis, and inflammation. Several studies have also confirmed their central roles in embryonic development and stem cell maintenance. Recently, GPCRs have emerged as key players in the regulation of cell survival, proliferation, migration, and self-renewal in pluripotent (PSCs) and cancer stem cells (CSCs). Our study and other reports have revealed that the expression of many GPCRs is modulated during the generation of induced PSCs (iPSCs) or CSCs as well as during CSC sphere formation. These GPCRs may have crucial roles in the regulation of selfrenewal and other biological properties of iPSCs and CSCs. This review addresses the current understanding of the role of GPCRs in stem cell maintenance and somatic reprogramming to PSCs or CSCs.
KW - Cancer stem cells (CSC)
KW - G protein-coupled receptor (GPCR)
KW - Induced pluripotent stem cell (iPSC)
KW - Somatic reprogramming
KW - Stem cell maintenance
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U2 - 10.5483/BMBRep.2015.48.2.250
DO - 10.5483/BMBRep.2015.48.2.250
M3 - Review article
C2 - 25413305
AN - SCOPUS:84925442405
SN - 1976-6696
VL - 48
SP - 68
EP - 80
JO - BMB Reports
JF - BMB Reports
IS - 2
ER -