G Protein-Coupled receptors –Potential roles in clinical pharmacology

Megan Kypreos, Teesta Banerjee, Debabrata Mukherjee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) constitute several membrane proteins that are turned on by hormones and neurotransmitters to trigger cellular signaling pathways. GPCRs have been targeted in the development of several drugs but the therapeutic potential of these proteins remains underutilized. Most drugs to date have targeted the class A, or the rhodopsin family of GPCRs, but recently the Class B, i.e., the secretin family of G protein receptors has been targeted for the treatment of metabolic diseases such as diabetes mellitus. Class B G protein-coupled receptors (GPCRs) have also been targeted for managing several clinical conditions such as diabetes mellitus, bone disorders, malignancies, neurodegeneration, cardiovascular diseases, neuropsychiatric disorders, etc. In this article, we review the medicinal chemistry and potential clinical role of targeting GPCRs with a special emphasis on cardiovascular pharmacology.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalCardiovascular and Hematological Agents in Medicinal Chemistry
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Beta-arrestin
  • Cardiovascular diseases
  • Diabetes
  • G protein-coupled receptor
  • Glucagon
  • Heart failure
  • Hypertrophy
  • Ligand
  • Rhodopsin
  • Secretin

ASJC Scopus subject areas

  • Hematology
  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'G Protein-Coupled receptors –Potential roles in clinical pharmacology'. Together they form a unique fingerprint.

Cite this