G Proteins and Regulation of Adenylate Cyclase (Nobel Lecture)

Alfred G. Gilman

Research output: Contribution to journalReview article

31 Scopus citations


How is the hormone‐activated synthesis of the second messenger cyclic AMP regulated? Or, in more general terms, how does the interaction of an extracellular agonist with a receptor lead to intracellular enzyme activity when receptor and enzyme are not distinct macromolecules? The mediators are membrane‐bound, guanine nucleotide binding regulatory proteins (G proteins). When the receptor is activated, G proteins dissociate into their subunits. These in turn activate or inhibit enzymes such as adenylate cyclases, which catalyze the synthesis of cyclic AMP. In these signal transmission processes G proteins act as molecular switches and amplifiers.

Original languageEnglish (US)
Pages (from-to)1406-1419
Number of pages14
JournalAngewandte Chemie International Edition in English
Issue number13-14
StatePublished - Jul 31 1995


  • G proteins
  • Nobel lecture
  • adenylate cyclases

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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